THE ROLE OF NITRIC OXIDE IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS

本研究的目的是测量一氧化氮（NO）的产生， 类风湿关节炎 将给予低硝酸盐和亚硝酸盐的饮食。 将采集血液、尿液和唾液，用于测量尿液 硝酸盐/亚硝酸盐排泄，巨噬细胞表达iNOS，NO-血红蛋白 通过电子顺磁共振，和S-亚硝基硫醇。 这些分析 将用于确定NO水平的增加是否与 疾病活动的临床和实验室测量。

The purpose of this study is to measure nitric oxide (NO) production in rheumatoid arthritis. A diet low in nitrate and nitrite will be given. Blood, urine, and saliva will be collected for measurement of urinary nitrate/nitrite excretion, iNOS expression by macrophages, NO-hemoglobin by electron paramagnetic resonance, and S-nitrosothiols. These analyses will be used to determine whether increased levels of NO correlate with clinical and laboratory measures of disease activity.