Taking Control: Understanding regulation of bacterial iron acquisition

该项目旨在揭示细菌调控网络作用于一个名为铁载体的偷铁分子家族。细菌利用铁载体从宿主、环境和彼此之间获取铁-因此，它们在微生物生命中起着核心作用。尽管它们很重要，但我们对这些偷铁武器是如何部署的却知之甚少。该项目将开发一种新的基于基因组学的高通量技术，用于定义细菌基因调控网络，并使用它来了解铁载体控制。这将提供铁载体功能的新知识，增强对细菌群落和宿主相互作用的理解，并在澳大利亚建立新的基因组学技术的领导地位。

This project aims to uncover the bacterial regulatory networks acting on a family of iron-stealing molecules called siderophores. Bacteria use siderophores to acquire iron from their hosts, the environment, and each other – as such, they have a central role in microbial life. Despite their importance, we have an incomplete knowledge of how these iron-stealing weapons are deployed. This project will develop a new genomics-based, high-throughput technology for defining bacterial gene regulation networks, and use it to understand siderophore control. This will provide new knowledge of siderophore function, enhance understanding of bacterial community and host interactions, and establish leadership in a new genomics technology in Australia.