NEURAL INJURY AND BLOOD FLOW ALTERATION AFTER CNS TRAUMA

该中心将研究星形胶质细胞作为介质的潜在作用， 在脑损伤后的早期阶段的细胞外环境。 的 中心还将开发脑血管疾病的临床指标 病理生理学，这将是有用的治疗评价。 还有， 将试图证明因果关系 星形胶质细胞功能的特定方面和脑血流之间 损伤后的调节异常。 项目有：1）“释放 细胞毒素和血管活性剂。“这个项目将测试 阻断阴离子转运抑制肿胀的假设， 星形胶质细胞和/或从星形胶质细胞释放兴奋性毒素。 第二 假设将检查乙醇对星形胶质细胞的影响。 第三 假设将涉及腺苷、H+和K+从星形胶质细胞释放。 （二） “阴离子通道抑制的损伤和保护机制。“这 该项目将测试有关负离子 通道抑制通过组织病理学改善脑损伤 技术. 第二个假设将关注乙醇水平的影响 头部受伤后的呼吸控制 3)“大脑评估 通过连续颈静脉血氧测定法进行氧合”。 这些临床研究 将尝试验证新的技术来量化的程度， 代谢和血流失调的时间和区域， 重伤患者。 我们将确定动脉静脉血氧 饱和度差可以用于连续地估计大脑 氧合状态 一个目标是建立可以用作 治疗评估的终点。 核心将包括一个 行政办公室（核心单元A），以及一个数据中心和统计 计算机设施（核心单元B）。 总体目标是建立 对头部受伤的病人进行临床研究， 并在体外和体内测试关于 发生二次损伤的机制。

This center will study the potential role of astrocytes as mediators of extracellular environment in the early stages following brain injury. The center will also develop clinical indices of cerebrovascular pathophysiology which will be useful in the valuation of therapies. Also, an attempt will be made to demonstrate a cause and effect relationship between specific aspects of astroglial function and cerebral blood flow regulation abnormalities following injury. Projects are: 1) "Release of cytotoxins and vasoactive agents from astrocytes." This project will test the hypothesis that blockage of anion transport inhibits swelling of astrocytes and/or release of excitotoxins from astrocytes. A second hypothesis will examine the effect of ethanol on astrocytes. A third hypothesis will involve adenosine, H+, and K+ release from astrocytes. 2) "Mechanisms of injury and protection by anion channel inhibition." This project will test hypothesis concerning the mechanisms whereby anion channel inhibition ameliorates brain injury by histopathological techniques. A second hypothesis will concern the effects of ethanol levels on respiratory control after head injury. 3) "Assessment of brain oxygenation by continuous jugular venous oximetry". These clinical studies will attempt to verify new techniques for quantifying the extent of metabolism and blood flow malregulation both temporally and regionally in severely injured patients. We will determine if arterial-venous oxygen saturation differences can be used to continuously estimate cerebral oxygenation status. A goal is to establish parameters that can be used as endpoints for therapy assessment. The core will consist of an administrative office (Core Unit A), and a data center and statistical computer facility (Core Unit B). Overall goals are to establish the means for conducting clinical research on head injured patients and to develop and test specific hypotheses both in vitro and in vivo regarding the mechanisms whereby secondary injury occurs.