FASEB RESEARCH CONFERENCE: TRANSCRIPTION REGULATION

通过转录进行基因调控是一个共同的基本过程 所有的生物系统。转录调控是关键 细胞行为的各个方面，包括增殖和分化以及 可能会推动发展过程中的关键事件。基因缺陷 监管与多种人类疾病有关，包括 癌症。这项申请要求为夏季FASE B会议提供资金 分化、发育和疾病的转录调控。 这次会议的目的是将从事 使用不同的方法研究广泛的转录过程 方法论和生物系统。我们的目标是提供一个深入的 对这一迅速扩大的领域的看法，使方法论和概念性 特定领域的进展可以迅速传播并应用于新的 问题和系统。每个会议会议都将讨论集中在一起 专注于转录研究关键领域的不同方法。这个 会议旨在提供最新进展的概述，范围 从蛋白质结构和基础和激活的基本机制看 转录到组织特异性转录、发育和致癌 转录因子。会议将强调这一重要作用 转录调控在正常分化和 基因异常表达的参与方式及其发生发展 癌症和其他疾病的起源。转录调控基因 脊椎动物胚胎发育，肌肉和血液的发育，以及 将特别强调荷尔蒙的调节。 会议将在加州大学圣克鲁斯分校举行 校园于1994年8月14日至19日举行。会议将包括正式会谈， 非正式的海报会议、讨论时段和充足的机会 与会科学家之间的互动。与会者将包括 首席研究员、博士后研究员和研究生。这个 会议将提供一个最新且经济高效的概述 是生物学中最基本和发展最快的领域之一 期望为进一步的研究提供新的想法和策略。

Gene regulation through transcription is a fundamental process common to all biological systems. Transcriptional regulation underlies critical aspects of cell behavior including proliferation and differentiation and is likely to drive key events during development. Defects in gene regulation have been linked to a wide variety of human diseases including cancer. This application requests funding for a summer FASEB conference on Transcriptional Regulation of Differentiation, Development and Disease. The intent of this conference is to bring together researchers engaged in studying a broad range of transcriptional processes using different methodologies and biological systems. The goal is to provide an in-depth view of this rapidly expanding field so that methodological and conceptual advances in specific areas can be rapidly disseminated and applied to new problems and systems. Each conference session groups together talks that focus on different approaches to key areas of transcription research. The sessions are designed to provide an overview of recent advances ranging from protein structure and fundamental mechanisms of basal and activated transcription to tissue specific transcription, development, and oncogenic transcription factors. The conference will underscore the important role that transcription regulation plays in normal differentiation and development and the manner in which aberrant gene expression in involved in the genesis of cancer and other diseases. Transcription control in vertebrate embryogenesis, in the development of muscle and blood, and in hormonal regulation will be particularly emphasized. The conference will be held at the University of California Santa Cruz campus from August 14-19 1994. The meeting will include formal talks, informal poster sessions, discussion periods and ample opportunity for interaction among the attending scientists. Attendees will include principal investigators, postdoctoral fellows and graduate students. The conference will provide an up-to-date and cost-effective overview of one of the most fundamental and rapidly moving fields in biology and is expected to generate new ideas and stratagems for further research.