NEW ION CHANNEL FORMING AMPHOPHILES

生物和化学之间的接口是一个重要而迅速的 扩大科学领域。对许多生物事件的理解是 被扩展到分子水平，以及化学家们对 化学反应性和结构，可以在这一新的 分子科学。以我的合成有机化学背景，我 为分子生物学系统的研究带来了一个非常重要的工具： 设计和准备新材料和物质的能力。在这 我的研究小组将准备和研究新的两亲性 分子以了解离子通道的结构要求 膜的形成和自组装。我们的长期计划包括 氢键网络在自组装过程中作用的进一步研究 组装工艺，天然产物与天然产物相互作用的研究 它们的生物靶标，以及新的合成方法和 支持这些项目的战略。

The interface between biology and chemistry is an important and rapidly expanding area of science. The understanding of many biological events is being extended to a molecular level, and chemists, with their insight into chemical reactivity and structure, can play an important role in this new molecular science. With my background in synthetic organic chemistry I bring a very important tool to the study of molecular biological systems: the ability to design and prepare new materials and substances. In this proposal my research group will prepare and study new amphophilic molecules to learn about the structural requirements for ion channel formation and self-assembly in membranes. Our long term plans include further studies on the role of hydrogen bonding networks in the self- assembly process, studies on the interaction of natural products with their biological targets, and the development of new synthetic methods and strategies to support these projects.