MOLECULAR BASIS OF SMOOTH MUSCLE DIFFERENTIATION

我的短期目标是把我的实验室发展成一个高效的 科学环境，利用当前的分子方法 调查正常和异常胚胎发生的问题。我的长期生活 目标是成为发展领域的杰出科学家 生物学，并极大地扩展了我们目前对过程的理解 参与正常和异常的胚胎发育。长期的 我们研究的目的是确定发育信号 平滑肌正常分化和成熟所必需的 细胞。我们计划研究导致这一现象的分子机制 通过确定平滑肌发育所必需的因素来实现 γ-平滑肌等肌动蛋白基因在大鼠脑内的正常表达 大鼠胃肠平滑肌细胞的分化和成熟 体外和体内。研究包括我目前研究的扩展 计划包括更详细的神经营养作用研究 交感神经节在平滑肌发育中的作用 血管内皮细胞正常发育的因素 转基因小鼠。

My short-term goals are to develop my laboratory into a highly productive scientific environment which utilizes current molecular approaches to investigate questions of normal and abnormal embryogenesis. My long-term goals are to become a preeminent scientist in the field of developmental biology and significantly expand our current understanding of the processes involved in normal and abnormal embryonic development. The long-term objective of our research is to determine the developmental signals necessary for the normal differentiation and maturation of smooth muscle cells. We plan to investigate the molecular mechanisms responsible for smooth muscle development by determining the factors necessary for the normal expression of the gamma-smooth muscle isoactin gene during the differentiation and maturation of gastrointestinal smooth muscle cells in vitro and in vivo. Studies include the expansion of my current research plan to include more detailed studies of the neurotrophic effects of sympathetic ganglia on smooth muscle development, and an analysis of the factors responsible for the normal development of smooth muscle cells in transgenic mice.