CHILDHOOD PRECURSORS & CLINICAL OUTCOME IN SCHIZOPHRENIA

所提出的研究是关于发展的一系列调查。 精神分裂症的先兆及其与临床结局的关系 特征--症状、神经心理特征和大脑 形态学。使用儿时的家庭电影，神经运动和 精神分裂症患者发展的社会情感方面将是 从婴儿期到青春期的记录，并与 兄弟姐妹和非家族对照以及情感性精神障碍患者 精神错乱。童年的各个方面之间的关系 成人患者的发展和特征将是 检查过了。这项研究还将探索孕期和孕期的作用 围产期因素和精神疾病家族史在预测中的作用 发育过程和临床转归。

The proposed research is a series of investigations of the developmental precursors of schizophrenia and their relation with clinical outcome characteristics -- symptoms, neuropsychological profiles and brain morphology. Using childhood home-movies, the neuromotor and socioemotional aspects of schizophrenic patients' development will be documented from infancy through adolescence, and contrasted with that of sibling and nonfamilial controls as well as patients with affective disorders. The relation between the various aspects of childhood development and the characteristics of patients as adults will be examined. The research will also explore the roles of prenatal and perinatal factors and family history of mental illness in predicting developmental course and clinical outcome.