NEURODEVELOPMENTAL & SOCIOEMOTIONAL ANTECEDENTS OF SCHIZ

这项提案中描述的研究涉及到确定 精神分裂症的发育前兆及其关系探讨 发育因素与神经心理学和神经解剖学之间的关系 精神分裂症的特点。这项研究使用的方法是 最好的描述是一种档案，观察的方法；童年的家- 电影将成为神经运动和社会情感的主要数据库 发展的各个方面，从婴儿期开始，一直延续到早期 青春期。受试者是死于精神分裂症的个人 青春期晚期[成年期早期]将有三个比较组； 被诊断为情感障碍的患者，患者的健康兄弟姐妹， 以及来自没有精神疾病的核心家庭的受试者。除了……之外 童年家庭电影，广泛的发展史和家族史数据 收集了所有主题的信息。患者和他们的兄弟姐妹对照将 还接受神经心理评估和磁共振成像 (核磁共振)脑扫描。以前授予的补助金将涵盖 收集档案数据和对研究对象进行评估。这项建议 要求提供资金以支付广泛观测的人员费用 录像带分析以及数据的组织、存储和分析。这个 该项目的主要目标是：1)绘制发展轨迹图 导致精神分裂症，2@确定潜势的关系 病因(围产期并发症和精神分裂症家族史 疾病)和发育特征，以及3)检验两者之间的关系 在病因、发育特点和 受试者成年后的神经心理学和神经解剖学方面。 因为研究的方法论将允许直接的微观层面 对儿童时期行为的分析，它有希望 产生了对精神分裂症前期发展的更广泛的看法 用以前的方法是可能的。

The research described in this proposal is concerned with identifying developmental precursors of schizophrenia and examining the relation between developmental factors and neuropsychological and neuroanatomical characteristics of schizophrenia. The research uses a methodology that is best described as an archival, observational approach; childhood home- movies will serve as the primary data-base on neuromotor and socioemotional aspects of development, beginning in infancy and extending through early adolescence. Subjects are individuals who succumbed to schizophrenia in late adolescence/early adulthood. There will be three comparison groups; patients diagnosed with affective disorder, healthy siblings of patients, and subjects from nuclear families with no mental illness. In addition to the childhood home-movies, extensive developmental and family history data are collected on all subjects. Patients and their sibling controls will also receive a neuropsychological assessment and magnetic resonance image (MRI) scan of the brain. Previously awarded grants will cover the collection of archival data and assessments of subjects. This proposal requests funds to cover the costs of personnel for extensive observational analyses of videotapes and organization, storage and analyses of data. The chief goals of the project are to: 1) chart the development trajectories leading to schizophrenia, 2@determine the relation between potential etiologic factors (perinatal complications and family history of mental illness) and developmental characteristics, and 3) examine the relations among etiologic factors, developmental characteristics, and neuropsychological and neuroanatomical aspects of the subjects as adults. Because the methodology of the study will allow for direct microlevel analyses of behavior across the childhood years, it holds promise for yielding a broader view of preschizophrenic development than has been possible with previous approaches.