Transforming the management of Urea Cycle Disorders using non-invasive breath ammonia monitoring

**尿素循环障碍（UCDs）是一种遗传性疾病，可导致严重的终身残疾和早期死亡**。它们会导致氨的积聚，这是有毒的，并导致严重和永久性的脑损伤。他们往往在出生时被诊断出来，直到疾病发作，在损害已经发生之前。这些情况很难处理，需要定期前往专科护理中心，这给家庭生活带来极大压力和破坏。它被形容为“就像生活在一颗定时炸弹里”。目前，氨只能在医院有效测量。在病人家中没有办法管理这些情况。为患者和家属提供一种在家测量和监测其氨的方法，将显著改善ucd的管理，并显著改善患者的生活质量和数量，同时也减轻了医疗保健系统的负担。**BreathDX正在与其区域合作伙伴，布里斯托尔大学，布里斯托尔大学和布里斯托尔大学医院和韦斯顿NHS信托合作，将其琥珀呼吸氨测量技术带给UCD患者**。AmBeR是一种使用简单，无创的方法，通过呼吸来测量氨水平。它有可能消除管理UCD的不可预测性，减少沉重的护理负担和与收入损失和获得保健服务所花费的时间相关的费用。通过改善急性和慢性护理管理，它也有可能改善患者的生活质量和数量。它还将减轻保健服务的负担，降低成本，提高效率和工作流程。

**Urea Cycle Disorders (UCDs) are genetic conditions which lead to severe lifelong disability and early death**. They cause a buildup of ammonia, which is toxic, and result in serious and permanent brain damage. They tend to go undiagnosed at birth until the onset of illness, before damage has already occurred. These conditions are very difficult to manage, requiring regular visits to specialist care centres, which is extremely stressful and disruptive to family life. It has been described as "like living with a time bomb". Currently, ammonia can only be measured effectively in the hospital. There is no way to manage these conditions in the patients' homes. Having a way for patients and families to measure and monitor their ammonia at home would lead to significant improvements in the management of UCDs, and lead to significant improvements in patient quality and quantity of life, while also reducing the burden on the healthcare system.**BreathDX is working with its regional partners, UWE Bristol, University of Bristol and University Hospitals Bristol and Weston NHS Trust to bring its AmBeR breath ammonia measurement technology to UCD patients**. AmBeR is a simple to use, non-invasive means of measuring ammonia levels using breath. It has the potential to eliminate the unpredictability of managing UCD, reducing the heavy care burden and costs associated with lost income and time spent accessing health services. It also has the potential to improve the quality and quantity of life of sufferers, by improving both acute and chronic care management. It would also reduce the burden on the health service, reducing costs and improving efficiency and workflow.