PRODUCTION OF RETROVIRUS STOCKS FOR AIDS RESEARCH

NIAID在该疾病的调查中发挥着核心作用 被称为获得性免疫缺陷综合症或艾滋病。 针对流行病学，预防， 发病机制和治疗疾病及其后遗症有 加强了。 艾滋病的控制将需要研究来了解宿主 免疫系统及其与艾滋病毒的相互作用 逆转录病毒 了解病毒宿主生物学的研究 相互作用，开发疫苗来预防感染， 抗病毒药物治疗已经感染的个体， 增强或重建免疫系统的方法将是 协助建立一系列标准化的逆转录病毒储存 为科学界。 本次征集的目的是支持研究活动 科学界和艾滋病项目的支持， 标准化的艾滋病毒、SIV和相关逆转录病毒库存。 一些病毒库存是可用的，但需要一个集中的 提供这些材料的资源至关重要。 NIAID需要 获得大量上述材料， 国家合作药物发现小组的努力， 国家疫苗开发小组、艾滋病临床研究中心、 研究小组，在基础研究的卓越计划， 艾滋病，以及NIAID发起的其他更具体的方案。

NIAID is playing a central role in the investigation of the disease known as Acquired Immunodeficiency Syndrome or AIDS. Research efforts directed toward the epidemiology, prevention, pathogenesis and treatment of the disease and its sequelae have intensified. The control of AIDS will require studies to understand the host immune system and its interactions with HIV and related retroviruses. Research to understand the biology of viral host interactions, to develop vaccines to prevent infection, to develop antiviral drugs to treat already infected individuals and to develop methods to boost or reconstitute the immune system will be assisted by establishing a series of standardized retroviral stocks for the scientific community. It is the purpose of this solicitation to support research activities of the scientific community and the AIDS Program by providing stocks of standardized HIV, SIV and related retrovirus stocks. Some virus stocks are available but the need for a centralized resource to provide these materials is essential. The NIAID needs access to significant quantities of the noted materials to support the efforts of the National Cooperative Drug Discovery Groups, the National Vaccine Developmental Groups, the AIDS Clinical Study Groups, the Programs of Excellence in Basic Research on AIDS, and other more specific programs initiated by NIAID.