ADDRESS FILE FOR CHILD HEALTH/DEVELOPMENT STUDIES

本合同的目的是增加有用性和 向科学界提供大型数据库， 儿童健康与发展研究的大量血清收集 （CHDS）。 目前的合同提案是前一份合同的后续提案。 一份旨在为CHDS编制用户指南的合同 数据库 用户指南已完成，所有数据库现在都已 存储在磁带上。 构成CHDS资源的数据和血清收集自 15,000个家庭的母亲、父亲和后代， 从1959年至1967年的怀孕以及1979年之前的家庭和子女。 这一巨大事业的基本原理是增加我们的 了解基因、生理、医学和环境 父母的因素影响子女的健康和发展。 CHDS数据文件和血清收集构成国家资源， 需要保持在一个有用的状态，以服务于调查人员从许多 科学学科的未来。 CHDS的重要方面 研究人群在于其未来研究的潜力， 与现存的数据库和血清收集。 的一项中心任务是 目前的建议是更新地址文件的当前地址， CHDS研究人群。 CHDS血清采集包括从18，400名患者中采集的70，000份样本。 孕妇，10,000个丈夫，3,000个新生儿。 将样品 抽血进行血型鉴定、常规实验室化学检查， 在-20 ℃下储存以备将来研究。 第二项重要任务是 目前的合同是将广泛的CHDS血清收集统一在一个 在其28年的历史上第一次安全。 血清采集的大量记录记录了 采血、受试者状态和制备、血清分离方法 和储存，以及各种研究者使用每个样本的历史 以及他们调查的目的 第三项主要任务 目前的合同是将积累的信息， 从笔记本和手写的大量血清收集样本 分类帐到磁性数据磁带，以提高有用的 独特的血清收藏

The purpose of this contract is to increase the usefulness and the availability to the scientific community of the large database and extensive serum collection of the Child Health and Development Studies (CHDS). The current contract proposal is a follow-on of a previous contract which was designed to develop a User's Guide to the CHDS Database. The User's Guide is completed and all of the database is now stored on magnetic tape. The data and the sera that comprise the CHDS resource were collected from mothers, fathers, and offspring of 15,000 families during 20,754 pregnancies from 1959-1967 and from the families and offspring until 1979. The rationale for this enormous undertaking is to increase our understanding of how genetic, physiologic, medical and environmental factors of parents affect the health and development of their offspring. The CHDS data files and serum collection comprise a national resource which needs to be maintained in a useful state to serve investigators from many scientific disciplines for years to come. An important aspect of the CHDS study population lies in its potential for future studies in conjunction with the extant data base and serum collection. A central task of the current proposal is to update the address file with current addresses of the CHDS study population. The CHDS serum collection consists of 70,000 samples taken from 18,400 pregnant women, 10,000 husbands, and 3,000 newborns. The samples were drawn for blood typing, routine laboratory chemistry, and for long-term storage at -20degreesC for future research. A second important task of the current contract is to unite the extensive CHDS serum collection in one safe place for the first time in its 28-year history. The extensive records of the serum collection document the circumstances of blood drawing, subject state and preparation, method of serum separation and storage, and the history of use of each sample by various investigators and the purpose of their investigations. The third major task of the current contract is to transfer the accumulated information about each sample of the extensive serum collection from notebooks and handwritten ledgers to magnetic data tape in order to improve the usefulness of the unique serum collection.