CONFERENCE ON PROCESSING OF PEPTIDE HORMONES

这次会议的目的是汇集研究肽的科学家 处理酶和细胞内分选机制， 细胞生物学、发育和遗传学的观点， 将出现对这些过程的全面理解。 的范围 这次会议将涉及的主题将是一个巨大的学习 经验，这将有利于青年科学家（学生和后， #21453;，以及科学家们。 此外，这次会议将举行 同时举行一次高度相关的Keystone会议， 将产生大量的多学科互动。 许多生物学上重要的蛋白质和肽都是通过合成而成的。 需要蛋白水解裂解的无活性前体 生物活性。 最近的进展导致确定了 负责这些激活步骤的几种酶，以及 蛋白质被定向到正确的细胞器， 发生蛋白水解加工。 此外，遗传缺陷与一些 最近已经在人、小鼠 在低等生物中;这些缺陷引起各种生理变化 包括肥胖不育和糖尿病 加工抑制剂 酶被开发用于广泛的应用， 抗病毒剂、抗高血压药、镇痛药和化疗药。 为了了解蛋白质和肽加工的复杂系统， 需要采取各种各样的办法。 这次会议的一个重要方面是 将汇集来自不同领域的科学家， 解决同样的问题，但使用不同的技术。 同学们， 博士后，和建立科学家将受益于接触， 不同的系统，以及合作的潜力;通过 合作，研究可以更有效地进行，所以NIH 会议的经费是合理的。

The aim of this meeting is to bring together scientists studying peptide processing enzymes and intracellular sorting mechanisms from biochemical, cell biological, developmental, and genetic perspectives so that a more comprehensive understanding of the processes will emerge. The range of topics to be covered at this meeting will be a tremendous learning experience that will benefit both junior scientists (students and post- docs) as well as established scientists. Also, this meeting will be held concurrently with a highly related Keystone meeting, and the joint format will produce a large number of multidisciplinary interactions. Many biologically important proteins and peptides are synthesized as inactive precursors that require proteolytic cleavage to become biologically active. Recent advances have led to the identification of several enzymes responsible for these activation steps, and the mechanism by which proteins are targeted to the correct cellular organelle where proteolytic processing occurs. In addition, genetic defects with some of the processing enzymes have recently been identified in humans, mice, and in lower organisms; these defects cause a variety of physiological changes including obesity, sterility, and diabetes. Inhibitors of the processing enzymes are being developed for a wide range of applications including antiviral agents, antihypertensives, analgesics, and chemotherapeutics. To understand the complex systems of protein and peptide processing, a wide array of approaches are needed. One important aspect of this meeting will be to bring together scientists from different fields, who are working on the same problems, but using different techniques. Students, post-docs, and established scientists will benefit from the exposure to different systems, and the potential for collaborations; through collaborations, research can be conducted more efficiently, and so NIH funding is well justified for the meeting.