MEETINGS ON THE ADIPOSE CELL & INSULIN ACTION SECRETION

在糖尿病和脂肪领域取得了重要进展 最近几年的细胞研究，就这些主题举行会议 非常及时。这些同时举行的会议将是多学科的， 将来自学术界和产业界的调查人员聚集在一起 细胞生物学、分子生物学、免疫学和生物化学 内分泌学和新陈代谢的临床学科。素数 目标是提出新的发现，以刺激交叉 共享基础和临床研究人员的受精情况 人类对激素分泌和信号转导及机制的兴趣 疾病。糖尿病是一种疾病，特点是 高血糖，损害β细胞胰岛素的未知分子缺陷 分泌和外周胰岛素反应性。在以下方面取得了显著进展 细胞和分子生物学研究揭示了一些相关的 II型糖尿病关键过程的组成和机制 综合症。共同的细胞信号元件，控制疾病和 胰岛素在肝脏、肌肉和脂肪中的作用包括：酪氨酸激酶；GTP- 结合蛋白，如ras和蛋白丝氨酸/苏氨酸激酶 瀑布。控制胰岛β细胞的胰岛素分泌涉及许多 这些相同的组件。脂肪细胞及其亲本脂肪组织 代表独特的实验系统，在其中理解 参与调控的各种信号通路的整合 差异化和发展性。脂肪细胞对一种 非常广泛的荷尔蒙引起了大量的井水 特征性反应，包括细胞/组织生长和发育， 底物运输、脂肪生成、脂肪分解和蛋白质运输 和分泌物。细胞内的许多特征 胰岛素信号系统及其在糖尿病中的破坏作用已被研究 在脂肪细胞中，由于细胞的胰岛素反应性 以及从患者和患者那里轻松地获得培养它们 实验动物。最近的进展突显了这一积极作用 脂肪组织也在糖尿病的代谢改变中发挥作用。 高血糖和高胰岛素血症对细胞胰岛素的影响 在脂肪细胞中的作用。分子机制涉及多种不同的 信号通路包括G蛋白调节的效应系统，如 作为腺酰环化酶和磷脂酶，受体相关和 胞浆酪氨酸激酶和磷酸酶。因为有重要的 糖尿病和肥胖症之间的关系；以及2)信号 参与免疫细胞反应、胰岛素分泌和 行动和脂肪细胞调控，这次会议应该提供一个 为基础和临床研究人员提供独特的科学形式 在激素作用和分泌的研究中。

Important advances have been made in the areas of diabetes and adipose cell research in recent years, making conferences on these topics extremely timely. These concurrent meetings will be multidisciplinary, bringing together investigators from academia and industry representing cell biology, molecular biology, immunology and biochemistry, and the clinical disciplines of endocrinology and metabolism. The prime objective is to present new findings that will stimulate cross- fertilization among basic and clinical investigators sharing common interests in hormone secretion and signaling and mechanisms of human diseases. Diabetes mellitus is a disease characterized by hyperglycemia, unknown molecular defects that impair beta cell insulin secretion and peripheral insulin responsiveness. Dramatic progress in cell and molecular biology research has revealed a number of related components and mechanisms underlying key processes in Type II diabetes syndromes. Common cellular signaling elements that control disease and insulin action in liver, muscle and fat include: tyrosine kinases; GTP- binding proteins such as ras; and protein serine/threonine kinase cascades. Control of insulin secretion in beta cells involves many of these same components. The adipose cell and its parent adipose tissue represent unique experimental systems in which to understand the integration of various signaling pathways involved in the regulation of differentiation and development. Adipose cells are responsive to a remarkably wide range of hormones which elicit a host of well characterized responses, including cell/tissue growth and development, substrate transport, lipogenesis, lipolysis, and protein trafficking and secretion. Much of the characterization of the intracellular insulin signaling system and its disruption in diabetes has been worked out in adipose cells, due to the insulin responsiveness of the cells and the ease of obtaining an culturing them from both patients and experimental animals. Recent advances have highlighted the active role the adipose tissue plays in the altered metabolism of diabetes as well as the impact of hyperglycemia and hyperinsulinemia on cellular insulin action in the fat cell. Molecular mechanisms involved in various signaling pathways include G-protein regulated effector systems such as adenylyl cyclase and phospholipases, receptor-associated and cytosolic tyrosine kinases and phosphatases. Since there are important relationships between: 1) diabetes and obesity; and 2) signaling pathways involved in immune cell responses, insulin secretion and action, and adipose cell regulation, this meeting should provide a unique scientific form for basic and clinical investigators involved in studies of hormone action and secretion.