DIETARY MANIPULATION IN UREMIA--NEPHROTIC AND CONTROLS

本项目提出：1)评估蛋白质需求和适应性 肾病综合征患者对尿蛋白丢失的反应， 以及2)确定代谢性酸中毒是否有助于 血液透析患者的营养不良。这项研究的第一部分 肾病治疗已接近尾声。6例慢性阻塞性肺疾病患者的治疗结果 极低蛋白质饮食的肾功能衰竭表明 全身蛋白质周转的代偿性变化在 长期治疗。这些结果最近发表在《美国医学会杂志》上。 物理。研究的第二部分，以评估代谢的影响 酸中毒对蛋白质代谢的影响进行了修订，现在是这个子集的一个子集 研究(见327A)。

This project proposes to: 1) evaluate protein requirements and adaptive responses to urinary protein losses in patients with nephrotic syndrome, and 2) to determine whether metabolic acidosis contributes to malnutrition in hemodialysis patients. The first part of the study in nephrotics is nearing completion. Results of 6 patients with chronic renal failure on a very low protein diet demonstrated that the compensatory changes in whole-body protein turnover are sustained during long-term therapy. These results were recently published in the Am J Physiol. Part 2 of the study to evaluate the impact of metabolic acidosis on protein metabolism was revised, and is now a subset of this study (see 327A).