IS SOCIAL DRINKING ASSOCIATED WITH INCREASED ISOPROSTANE PRODUCTION?

这项研究的目的是确定社会对酒精的消费 与增加8-表前列腺素F2α的形成有关，这是一种新的 自由基催化的脂质过氧化的标志物。自由基团 世代与多种疾病状态有关。研究 然而，在这一领域，主要表现为间接和间接的 自由基与疾病的联系。造成这种情况的主要原因有 一直是用于量化自由基的技术的不足 队形。此外，从动物研究中获得的大部分结果 血液酒精含量超过200毫克/毫升。这 这项研究旨在寻找人体内产生自由基的证据。 人类，通过测量8-表-前列腺素F2α，对较小的 酒精的量。调查人员打算将这项研究扩大到 探索脂肪酸消费、社交酒精之间的相互作用 摄入量和自由基生成与这些试点数据。

The aim of this study is to determine if social consumption of alcohol is associated with increased formation of 8-epi PGF 2 alpha, a novel marker of free-radical catalyzed lipid peroxidation. Free radical generation is implicated in a wide variety of disease states. Research in this area, however, has shown largely indirect and circumstantial association of free radicals and disease. The main reasons for this has been the inadequacy of the techniques employed to quantify free radical formation. In addition, most of the results obtained from animal studies are in the setting of blood alcohol levels in excess of 200 mg/ml. This study is designed to look for evidence of free radical generation in humans, by measurement of 8 epi-PGF 2 alpha, in response to smaller amounts of alcohol. The investigators intend to expand the study to explore the interaction between fatty acid consumption, social alcohol intake and free radical generation with these pilot data.