Market Evaluation of proposed point of care medical diagnosis and monitoring through the measurement of ammonia in breath using a hand held device containing an electrochemical sensor selective to this analyte.

已经有相当多的研究将呼吸中的化学物质的存在、食欲和疾病或障碍联系起来。研究表明，有30多种疾病存在这种联系。诊断通常依赖于对血液、唾液、尿液和粪便的分析。这对个体来说可能是侵入性的或令人不快的，而且实验室在获得结果方面可能会有重大延误。一种用于快速诊断和治疗疾病的手持式呼吸捕捉设备具有很高的医疗和家庭使用潜力。目前可用于乳糖不耐受和哮喘发炎的呼吸测试。该设备价格昂贵，体积庞大，限制了摄入量。我们的初步市场研究表明，氨水平升高与九种不同的情况有关。我们的目标是开发一种使用电化学传感器来测量氨的手持式呼吸设备，作为一系列呼吸诊断设备中的第一种。呼气氨的两个吸引人的适应症是测量透析在终末期肾病中的有效性，以及在诊断幽门螺杆菌感染方面的有效性。这项建议将对这些潜在的市场进行深入分析，包括咨询顾问和全科医生的市场参考。

There has been a considerable research into chemicals in breath linking their presence, orexcess, with disease or disorders. There are over 30 diseases where research has made thislink. Diagnosis is often dependent on the analysis of blood, saliva,urine and stools. It can beinvasive or unpleasant for the individual, and there can be significant Laboratory delays inobtaining results. A point of care hand held device capturing breath for speedy diagnosis andmanagement of disease has high potential for medical and home use.Breath tests are currently available for lactose intolerance and for management of asthmainflammation. The equipment is expensive and bulky limiting uptake.Our initial market research has indicated that elevated levels of ammonia are associated withnine different conditions. Our aim is to develop a hand held breath device using anelectrochemical sensor to measure ammonia, as the first of a range of breath diagnosticdevices.Two attractive indications for breath ammonia are measuring the effectiveness of dialysis inend stage renal disease, and in the diagnosis of Helicobacter Pylori infection.This proposal will carry out in depth analysis of these potential markets including marketreferencing with consultants and General Practioners.