TUMOR EVALUATION BY ENDOLUMINAL 2D AND 3D ULTRASOUND

该项目的目的是评估二维 (2D)和三维（3D）腔内超声，导致其用于 诊断和分期各种肿瘤。该研究计划包括 三个要素：1）2D和3D腔内超声性能研究 使用体模; 2）使用动物评估3D超声成像 肿瘤模型及多种三维重建模型的验证; 3)人体肿瘤的临床2D和3D验证。该项目将重点 三种肿瘤：尿路上皮，子宫内膜和食管。的 候选人刘吉斌博士对评估 肿瘤在身体的各种领域使用这样的动物模型， 兔VX 2肿瘤和土拨鼠肝癌。他在动物方面的专业知识 自他加入以来的四年里， 超声诊断部。候选人有广泛的 在各种动物中使用微型传感器的经验 在过去的四年里，病人和病人。候选人将采取 计算机科学、生物统计学、物理学和工程学课程， 扩大他的知识基础。候选人的担保人，巴里B。戈德堡， 医学博士，诊断超声部主任和杰斐逊 超声研究和教育研究所，已超过三十个 多年的超声经验，并已在许多研究者 赠款。候选人的其他导师包括一位超声物理学家， 计算机科学家和生物统计学家有一项重要的研究 可用的材料和空间。这包括超声物理学 实验室，配备超声波和X射线设备的动物设施， 一个计算机中心，有现有的三维重建程序。

The aim of this project is to evaluate the capabilities of 2-dimensional (2D) and 3-dimensional (3D) endoluminal ultrasound leading to its use to diagnose and stage a variety of tumors. This research plan comprises three elements: 1) 2D and 3D endoluminal ultrasound performance studies using phantoms; 2) evaluation of 3D ultrasound imaging using an animal tumor model and validation of a variety of 3D reconstructional models; 3) clinical 2D and 3D Validation in human tumors. The project will focus on three tumors: uroepithelial, endometrial and esophageal. The candidate, Dr. Ji-Bin Liu, has particular interest in evaluation of tumors in a variety of areas of the body using such animal models as rabbit VX2 tumors and woodchuck hepatomas. His expertise in animal experimentation has evolved over the four years since he joined the Division of Diagnostic Ultrasound. The candidate has had extensive experience working with miniature transducers in a variety of animal models and patients over the past four years. The candidate will take courses in computer science, biostatistics, physics and engineering to extend his knowledge base. The candidate's sponsor, Barry B. Goldberg, M.D., Director of the Division of Diagnostic Ultrasound and the Jefferson Ultrasound Research and Education Institute, has had more than thirty years of experience in ultrasound and has been an investigator on many grants. The candidate's other mentors include an ultrasound physicist, a computer scientist and a biostatistician. There is significant research material and space available. This includes an ultrasound physics laboratory, an animal facility with ultrasound and x-ray equipment and a computer center with existing 3D reconstruction programs.