PREDICTING PROGRESSION TO DYSPLASIA--ULCERATIVE COLITIS

我几乎完成了我的胃肠病学研究，现在我正在用我的 作为临床研究人员和分子遗传学家需要解决的新技能 胃肠道肿瘤早期诊断及发病机制中存在的问题。我 在分子生物学医学院工作了六年，部分 跟上了医学遗传学的进展 学校和我的实习医生。我已经得到了这个机会 监督独立提出假设、设计实验和 把它们拿出来。我发现与溃疡性结肠炎患者一起工作 罹患癌症的高风险是促进我的 将BASIC的发现减少到临床实践的主要兴趣 科学。我有一种强烈的愿望，想了解更多关于 胃肠道癌症。本实验室所做的研究类型以及 可以为我提供建议的同事是实现这一目标的理想方式。 我的主要赞助人是鲁宾医生，临床研究员，胃肠病专家， 曾指导过多位优秀的学术胃肠病专家。我的同事- 赞助商是杰出的胃肠病专家罗杰·哈吉特博士 病理学家和李森博士，一位出色的临床研究教师。这个 为我提供的实验室设施非常充足，我所有的 赞助商承诺帮助支持我的研究，尽管目前 艰难的金融环境。 我们研究小组的长期目标是取得更好的成绩 对肿瘤进展的分子机制的认识 与溃疡性结肠炎相关的不典型增生和癌症。在这个过程中，我们 希望开发出更早、更具成本效益的诊断方法 可治愈的癌症及其前驱疾病。我们希望在三年内完成这些研究 方式： 1.应用分子遗传学技术对大肠切除标本进行研究 结肠癌的发病机制。 2.前瞻性研究监视结肠镜检查中的活检 寻找预测异型增生的标志物。 3.开发筛查血液测试，以UC患者为最高目标 有发生不典型增生或癌症的风险。 我目前正在管理一个分子遗传学的日常运作 实验室由拉比诺维奇博士协助。在…的支持下 这个K08我希望完成我的分子遗传学培训，并 继续开展合作研究。

I have almost completed my fellowship in gastroenterology and am using my new skills as a clinical investigator and molecule geneticist to solve problems in early diagnosis an pathogenesis of gastrointestinal cancer. i worked for six years in molecular biology medical school and have partially caught up with progress in medical genetics which occurred during medical school and my residency. I have been given the opportunity under supervision to independently pose hypotheses, to design experiments and to carry them out. I have found that working with ulcerative colitis patients at high risk for developing cancer is an excellent way to further my primary interest in reducing to clinical practice the discoveries of basic science. I have a strong desire to learn more about the pathogenesis of gastrointestinal cancer. The type of research done in this laboratory and the colleagues available to advise me are ideal ways to attain this goal. My primary sponsor is Dr. Rubin clinical investigator, gastroenterologist, and past mentor of many excellent academic gastroenterologists. My co- sponsors are Dr. Rodger Haggitt, an outstanding gastrointestinal pathologist and Dr. Sum Lee, a superb clinical investigator teacher. The laboratory facilities available to me are more than adequate and all of my sponsors have promised to help support my research despite the current difficult financial environment. The long term objective of our research group is to gain better understanding of the molecular mechanisms of neoplastic progression in the dysplasia and cancer associated with ulcerative colitis. In the process we hope to develop earlier and more cost effective methods of diagnosing curable cancer and it's precursors. We hope to do these studies in three ways: 1. To use molecular genetic techniques on colectomy specimens to study the pathogenesis of colon cancer. 2. To prospectively study biopsies taken during surveillance colonoscopy to find markers predictive of dysplasia. 3. To develop a screening blood test to target the UC patients at highest risk for developing dysplasia or cancer. I am currently managing the day to day operation of a molecular genetics laboratory with the assistance of Dr. Rabinovitch. With the support of this K08 I hope to complete my training in molecular genetics and to continue collaborative research.