MICROBE PATHOGEN GENOME PROJECT--A ACTINOMYCETEMCOMITANS

描述(改编自调查者摘要)： 应用，研究人员建议确定核苷酸序列 伴放线放线杆菌基因组(以下简称 因为显而易见的原因)。AA是局限性青少年的病原体 牙周炎(LJP)，至少困扰着70,000名儿童和青少年 每年在美国。LJP是一种慢性牙龈炎症性疾病 (牙床)和潜在的骨组织，没有有效的预防措施。近期 数据表明，再生障碍性贫血也与其他牙周病有关。 引起危及生命的口外感染。从分类上讲 AA与流感嗜血杆菌关系密切。这是一个高度的 AA基因组测序项目的吸引人的特点。从这个观点来看 一位研究微生物发病机制的学生，流感嗜血杆菌基因组序列 有几个具体的问题，尽管这一点非常重要 成就。这些研究将避免危及H。 流感病毒数据库。事实上，AA基因组序列可能会增强 流感嗜血杆菌序列的利用，除了提供重要的 关于戒酒协会的信息。因此，调查人员提出了一个单一的具体目标 项目：测定和分析2.2Mb的核苷酸序列 AA株CU1000的基因组。

DESCRIPTION (Adapted from the Investigator's Abstract): In this application, the investigators propose to determine the nucleotide sequence of the genome of Actinobacillus actinomycetemcomitans (hereafter abbreviate Aa for obvious reasons). Aa is the causative agent of localized juvenile periodontitis (LJP), afflicting at least 70,000 children and adolescents each year in the US. LJP is a chronic inflammatory disease of the gingiva (gums) and underlying bony tissues, with no effective prevention. Recent data suggests that Aa is also involved in other periodontal disease syndromes, and causes life-threatening extraoral infections. Taxonomically Aa is closely related to Haemophilus influenzae. This is a highly attractive feature of the Aa genome sequencing project. From the viewpoint of a student of microbial pathogenesis, the H. influenzae genome sequence has several specific problems, despite the singular importance of that achievement. The studies will avoid pitfalls that compromised the H. influenzae database. Indeed, the Aa genomic sequence may enhance the utility of the H. influenzae sequence, in addition to providing important information on Aa. Thus, the investigators propose a single specific aim for the project: to determine and analyze the nucleotide sequence of the 2.2 Mb genome of Aa strain CU1000.