Global positioning system for small molecules: accelerating lead discovery

该项目旨在建立一种工具，以加速从非常小的分子产生铅。这将改变小分子识别的模式，这些小分子可以作为开发特定探针或药物的先导化合物。该项目提供了一种从化合物片段库中快速生成先导化合物的新策略。新方法有望促进新铅分子的鉴定和开发，借鉴在基于片段的铅发现领域取得的进展，这在制药工业中越来越多地使用。所开发的工具也可以应用于生物过程的成像。通过开发新技术，该项目应提供具有商业化潜力的知识产权。

This project aims to establish a tool to accelerate lead generation from very small molecules. This will shift the paradigm in the identification of small molecules that can serve as lead compounds for the development of specific probes or drugs. This project offers a new strategy to rapidly generate lead compounds from a library of compound fragments. The new approach is expected to facilitate identification and development of new lead molecules, drawing on advances made in the field of fragment-based lead discovery, which is increasingly used in the pharmaceutical industries. The tools developed can also be applied for imaging of biological processes. By developing new technologies, the project should deliver intellectual property with potential for commercialisation.