MCP-4 AND LEUKOCYTE TRAFFICKING AND ACTIVATION

趋化因子是一类分泌的蛋白质家族，它们扮演着关键的 调节不同类型While血细胞的作用 组织损伤的感染部位。对宿主免疫的调节 这些分子的反应对于对抗细菌和 病毒感染，以及破坏转化的细胞 否则会导致肿瘤。然而，不适当的监管或 这些分子的表达可能导致免疫功能失调。 可能导致各种炎症条件的反应， 包括过敏性和自身免疫性疾病。因此， 了解免疫调节分子的作用，如 趋化因子对新药的发展具有重要意义 免疫疗法，以抑制不适当的炎症反应。 这些知识也将与新疫苗的设计有关。 这将增强宿主对肿瘤生长的免疫反应。 这项建议的目的是进一步描述生物 新发现的趋化因子MCP-4的活性。的表达 相关的趋化因子是由细菌脂多糖诱导的， 是科利毒素的活性成分。一些趋化因子有 已被证明对促进动物肿瘤消退有效 模型；其他人与哮喘、牛皮癣和 动脉硬化。因此，了解MCP-4的属性是 对于评估其治疗潜力是必不可少的。

Chemokines are a family of secreted proteins that play a critical regulatory role in directing different types of while blood cells to sites of infection of tissue damage. Regulation of the host immune response by such molecules is important for combating bacterial and viral infection, and for the destruction of transformed cells that could otherwise lead to tumors. However, the improper regulation or expression of these molecules can lead to a dysregulated immune response that can contribute to a variety of inflammatory conditions, including allergic and autoimmune diseases. Consequently, understanding the roles of immuno- regulatory molecules such as chemokines is important for the development of new immunotherapies to inhibit an inappropriate inflammatory response. This knowledge would also be relevant to the design of new vaccines that would augment the host immune response to tumor growth. The aim of this proposal is to further characterize the biological activities of a newly discovered chemokine, MCP-4. Expression of related chemokines is induced by bacterial lipopolysaccarides, which are an active component of Coley's toxins. Some chemokines have been shown to be effective for promoting tumor regression in animal models; others have been associated with asthma, psoriasis and atherosclerosis. Therefore, understanding the properties of MCP-4 is essential for evaluating its therapeutic potential.