Process Scale-up using the CPI National Industrial Biotechnology Facility

Coressence Ltd开发了一种先进的植物营养素提取工艺，该工艺在TSB项目J 9009（2006-8）下以“低于千克”的规模运行，使用Critical Processes Ltd作为分包商。该工艺从选定的苹果品种中生产出具有高产率表儿茶素单体（>30% w/w）和黄烷-3-醇低聚物的商业产品。表儿茶素是一种食品，补充剂和医疗食品为基础的血管扩张剂，而低聚物是有效的抗血管生成产品，用于皮肤护理和医疗食品。Coressence通过一系列直接销售、全球许可和合作安排销售这些产品。该项目将进行“100公斤”规模装置的放大试验，作为“1000公斤”工艺开发和建设的第一阶段。该项目将进行详细的工艺升级，同时考虑到满足商业和工业标准所需的必要标准。该项目将涉及最近委托使用的设备，作为威尔顿中心开放获取的英国工业生物技术研究所国家工业生物技术设施的一部分。

Coressence Ltd developed an advanced phytoneutrient extraction process operating at "sub kg" scale under TSB project J9009 (2006-8) using Critical Processes Ltd as a subcontractor.The process produces a commercial product with a high yield epicatechin monomer (>30% w/w) and flavan-3-ol oligomers from selected apple varieties. Epicatechin is a food, supplement and medical food-based vasodilator while oligomers are effective anti-angiogenic products which are used in skin care and medical foods. Coressence markets these products through a range of direct sale, global licensing and collabrative arrangements. This project will undertake scale-up trials for a "100 kg" scale unit as the first stage in the devlopment and construction of a "1000 kg" process. The project will undertake detailed process up-scaling taking account of the necessary criteria required to meet commercial and industry standards.The project will involve the use equipment recently commissioned as part of the open access UKCPI National Industrial Biotechnology Facility at the Wilton Centre.