IMPACT OF NOCTURNAL HYPOGLYCEMIA ON THRESHOLD COGNITIVE DYSFUNCTION IN IDDM

为了检验较低的血糖浓度是 需要引起低血糖认知功能障碍， 胰岛素依赖型糖尿病患者低血糖的前因 在两种情况下研究一次夹闭夜间 (2330- 0300小时）低血糖（约2.5 mmol/L）， 夹闭夜间Euronectin（约6.1 mmol/L）。 高胰岛素血症阶梯式低血糖（约6.1、4.7、4.2、3.6、3.1和 2.5 mmol/L）钳夹，以评估血糖 低血糖认知功能障碍以及 神经内分泌和症状反应。

To test the hypothesis that lower plasma glucose concentrations are required to cause hypoglycemic cognitive dysfunction following recent antecedent by hypoglycemia patients with insulin dependent diabetes mellitus (IDDM) are studied on two occasions once with clamped nocturnal (2330 - 0300 hours) hypoglycemia (approx. 2.5 mmol/L) and once with clamped nocturnal euglycemia (approx. 6.1 mmol/L) in random sequence. Hyperinsulinemic stepped hypoglycemic (approx. 6.1, 4.7, 4.2, 3.6, 3.1 and 2.5 mmol/L) clamps are performed the following morning to assess glycemic threshold for hypoglycemic cognitive dysfunction as well as for neuroendocrine and symptomatic responses.