CONVENTIONAL AND ALTERNATIVE HEALTH PROMOTION

研究计划的广泛、长期目标是确定 是否有可能，使用多种方式的生活方式干预， 显著改变"正常老化"，即减缓、停止甚至逆转 与衰老有关的衰退。3年研究的具体目标 进行一项单盲对照临床试验， 传统和替代多模态干预的效果 相对于常规护理控制， 健康和成功的老龄化：1）生理措施，包括血液 血压、胆固醇、DNA损伤、脂质过氧化物、体重， 肌肉骨骼灵活性和神经激素（DHEA，生长调节素 激素，皮质醇）; 2）认知测量，包括短期和长期 记忆，认知灵活性，选择反应时间，流体和 晶体智力; 3）心理生活质量测量 包括生活满意度，心理困扰，自我效能感， 健康心理控制源、整体健康、自我发展与自我 一体化这项新资助的研究将在 跨学科团队的方向，使用基于社区的样本， 165名老年人（> 65岁）。它会提供有价值的信息 关于多因素的潜在机制和协同效应 方式方法成功老龄化。因为这项研究提供了一个 对一种主要的替代医学方法进行严格的实证研究， 美国国立卫生研究院的替代医学办公室表示了强烈的兴趣， 资助这项提案。

The broad, long-term objective of the research proposal is to determine whether it is possible, using multi-modality lifestyle interventions, to significantly modify "usual aging", i.e. to slow, stop or even reverse decrements associated with aging. The specific aims of the 3-year study are to conduct a single-blind, controlled clinical trial comparing the effects of a conventional and an alternative multi-modality intervention relative to a usual care control on three sets of variables relevant to health and successful aging: 1) Physiological measures including blood pressure, cholesterol, DNA damage, lipid peroxides, body weight, musculoskeletal dexterity, and neurohormones (DHEA, somatomedin growth hormone, cortisol); 2) Cognitive measures including short- and long-term memory, cognitive flexibility, choice reaction time, fluid and crystallized intelligence; 3) Psychological quality of life measures including life satisfaction, psychological distress, self-efficacy, health locus of control, global health, self-development and ego integration. This newly-funded study will be conducted under the direction of an interdisciplinary team using a community-based sample of 165 elderly individuals (>65 y.o.). It will yield valuable information on the underlying mechanisms and the synergistic effects of multi- modality approaches to successful aging. Because this study provides a rigorous empirical investigation of a major alternative medical approach, NIH's Office of Alternative Medicine has expressed a strong interest in funding this proposal.