The nature of standing genetic variation

该项目旨在扩大对个体表型差异背后的遗传变异的理解。遗传变异的性质在生物学中具有广泛的后果，从检测因果遗传变异到适应自然种群。这个项目将采用一种新颖的实验方法来测试几个长期存在的假设，即新突变对个体特征的影响及其对适应度的联合多效性影响。通过扩大我们对突变、选择和漂移如何相互作用的理解，这个项目可以显著提高我们对表型的遗传基础的理解，以及我们预测表型进化的能力。

This project aims to expand understanding of the genetic variation underlying phenotypic differences among individuals. The nature of genetic variation has broad consequences across biology, from the detection of causal genetic variants to the adaptation of natural populations. This project will take a novel experimental approach to test several long-standing assumptions about the effects of new mutations on individual traits and their joint pleiotropic effect on fitness. By expanding our understanding of how mutation, selection and drift interact, this project could provide significant improvements in our understanding of the genetic basis of phenotypes, and our ability to predict phenotypic evolution.