COGNITIVE/LINGUISTIC FACTORS IN ACQUIRED DYSLEXIA

阅读能力的中断是一种常见的、令人衰弱的疾病 局灶性脑损伤的后果，如中风。“获得者” 阅读障碍，发生在病前识字的成年人中，可以采取一种 看起来反映选择性的不同形式的数量 认知操作的不同方面的损害 通常支持阅读。这个项目的长期目标是 开发一种描述这些认知的阅读模式 操作及其交互作用。这样的模型将有一个 各种应用程序。如果特定的阅读障碍症状可以是 被解释为由 模型，然后可以将补救症状的尝试集中在 负责任的代表或过程。此外，离散的 通过对加工过程的研究确定的加工成分 有神经性阅读障碍的患者可能会 是最终被证明与以下组件相关的组件 可识别的神经生物学过程。该计划的具体目标 下一个项目期将继续调查这些关系 在不同的处理组件中，假设 全神贯注地阅读。建议进行实验，以扩大 重点调查句法和语义的贡献 阅读和写作成绩的操控。三 与上一个项目一样，将使用方法学方法 句号。主要方法将是对患有以下疾病的患者进行测试 实验电池上的获得性阅读障碍和对照组受试者 旨在识别假设范围内的选择性损害 正在处理组件。第二种方法论方法是 继续开展靶向治疗研究，在 哪些尝试是为了改变患者的特定方面 处理能力，以便改变对其他人的影响 可以对组件进行评估。第三种方法是开发 已实施的计算版本的指南 加工模型，使具体假设的时间进程 并且可以探索特定组件的交互作用。

Disruption of the ability to read is a common and debilitating consequence of focal brain injury, suCh as stroke. The "acquired" dyslexias, occurring in premorbidly literate adults, can take a number of distinct forms that appear to reflect selective impairment of different aspects of the cognitive operations that normally support reading. The long-term goal of this project is to develop a model of reading that describes those cognitive operations and their interactions. Such a model would have a variety of applications. If specific dyslexic symptoms can be interpreted as arising from identifiable processing deficits within a model, then attempts to remediate symptoms can be focused on the responsible representation or process. Moreover, discrete components of processing that are identified through studies of the patients with neurogenic reading impairments would be likely to be the components that will ultimately prove to be related to identifiable neurobiological processes. The Specific Aims for the next project period continue investigations of the relationships among the distinct processing components that are hypothesized to be involved in reading. Experiments are proposed to extend the focus to investigate the contribution o syntactic and semantic manipulations on reading and writing performance. Three methodological approaches will be used, as in the previous project period. The primary method will be the testing of patients with acquired dyslexia and control subjects on an experimental battery designed to identify selective impairments within hypothesized processing components. A second methodological approach to be continued is the development of targeted treatment studies, in which attempts are made to change specific aspects of patients' processing abilities so that th effects of change on other components can be assessed. A third approach is the development of an implemented computational version of the guiding processing model, so that specific hypothese about the time-course and interactions of specific components can be explored.