RNA surveillance and the initial steps of RNA biogenesis

该项目旨在了解RNA生物发生的初始步骤以及该过程如何与染色质环境相关联。虽然我们的基因组中只有不到5%编码蛋白质，但几乎整个基因组都被转录为RNA。这些转录本中的大部分在RNA生物合成的早期阶段被RNA监视机制降解，但这些转录本的识别和降解机制尚不清楚。新的证据表明，转录位点的染色质环境在这一过程中起着重要作用。该项目将在实施新兴的基于RNA的技术和理解如何保持基因组稳定性方面带来重大利益。

This project aims to understand the initial steps of RNA biogenesis and how this process is linked to the chromatin environment. Although less than five per cent of our genome encodes proteins, almost the entire genome is transcribed to RNA. A large portion of these transcripts are degraded during the early steps of RNA biogenesis by the RNA surveillance machinery, but the mechanism for the recognition and degradation of these transcripts is not understood. New evidence suggests that the chromatin environment of the transcribed locus plays an important role in this process. This project will lead to significant benefits in the implementation of emerging RNA-based technologies and in understanding how genome stability is maintained.