VACCINES ELICITING CD8 CYTOTOXIC T CELL RESPONSES

感染HIV-1的人通常会产生强大的抗病毒CD8 细胞毒性T淋巴细胞(CTL)反应。CTL似乎扮演着一个 在减少病毒载量方面发挥重要作用，但感染通常持续存在 最终会恶化。这个项目的长期目标是 促进旨在生产更多疫苗的疫苗的开发 有效的CD8 CTL反应比在自然过程中发生的 感染。为此，我们将定义最有效的形式 热休克融合蛋白和DNA载体作为免疫原诱导 初发和记忆性CD8细胞毒性T淋巴细胞(CTL)应答 一种转基因小鼠模型及其最终应用 非人灵长类(猕猴？)疫苗的免疫原 抗SIV感染。

Individuals infected with HIV-1 often make vigorous anti-viral CD8 cytotoxic T lymphocyte (CTL) responses. The CTL appear to play an important role in reducing the viral load but infection usually persists and eventually worsens. The long-term goal of this project to is facilitate the development of vaccines aimed at generating more effective CD8 CTL responses than occur in the course of natural infection. To this end we will define the maximally effective forms of heat shock fusion protein and DNA vectors as immunogens for eliciting potent primary and memory CD8 cytotoxic T lymphocyte (CTL) responses in a transgenic mouse model with aim of eventually applying related immunogens to the vaccination of nonhuman primates (macaque monkeys?) against SIV infection.