OVARIAN CANCER GENE THERAPY WITH BRCA1

我们正在研究阻止卵巢生长的可能性 通过增加与癌症相关的主要基因的表达 遗传性卵巢癌，BRCA1。我们已经证明了这种基因 BRCA1转移到癌细胞中抑制其生长并减少 人癌细胞在裸鼠体内的致瘤作用。因为BRCA1出现了 作为一种分泌型生长抑制因子，它是基因治疗的理想基因 研究是因为只有中等比例的肿瘤转导 显然，细胞产生足够的生长抑制物来抑制所有肿瘤 细胞。这项研究的目的是使用一种禁用的老鼠病毒来 将BRCA1基因导入卵巢癌细胞，以确定这是否 会抑制癌细胞在体内的生长和扩散 有耐心的。

We are studying the possibility of arresting the growth of ovarian cancer by increasing expression of the major gene responsible for hereditary ovarian cancer, BRCA1. We have demonstrated that gene transfer of BRCA1 into cancer cells inhibits their growth and reduces tumorigenesis of human cancer cells in nude mice. Because BRCA1 appears be a secreted growth inhibitor, it is an ideal gene for gene therapy studies because transduction of only a moderate percentage of tumor cells apparently produces enough growth inhibitor to inhibit all tumor cells. The purpose of this study is to use a disabled mouse virus to introduce the BRCA1 gene into ovarian cancer cells to determine if this will inhibit the growth and spread of the cancer cells within the patient.