SPECT IMAGING OF DOPAMINE FUNCTION IN SCHIZOPHRENIA

与以前的研究一样，安非他明诱导的多巴胺释放是 通过测量多巴胺D2受体可用性的减少来估计 [123]IBZM。 苯丙胺诱导的{123 I}IBZM结合减少 精神分裂症患者组的电位显著高于 对照组在精神分裂症患者组， 对{123 I]IBZM结合潜力的影响与羽化或 精神病症状恶化该结果提供了直接 有证据表明，急性安非他明引起的精神病症状， 精神分裂症患者与过度刺激有关， 多巴胺能传递，并建议异常反应， 精神分裂症中的多巴胺能神经元

As in previous studies, the amphetamine-induced dopamine release was estimated by the reduction in dopamine D2 receptor availability measured with {123I]IBZM. The amphetamine-induced decrease in {123I}IBZM binding potential was significantly larger in the schizophrenic group compared to the control group. In the schizophrenic group, the elevated amphetamine effect on {123I]IBZM bindng potential was associated with emergence or worsening of positive psychotic symptoms. This result provide direct evidence that psychotic symptoms elicited by acute amphetamine in schizophrenic patients are associated with exaggerated stimulation of dopaminergic transmission and suggest an abnormal responsiveness of dopaminergic neurons in schizophrenia.