AEROBIC EXERCISE IN CYSTIC FIBROSIS

囊性纤维化（CF）是最常见的遗传性缩短寿命的疾病 在白色人群中， 肺功能、运动耐量和生活质量。 先前 短期研究表明，CF患者可能受益于 有氧运动，改善心肺功能，锻炼 容忍，也许是改善或延迟预期的 肺功能恶化。 最近的观察证实， 有氧健身和患者生存率之间的强相关性 CF没有发表过使用行为医学的研究 技术，以确保遵守长期有氧运动计划 对于8 - 18岁的CF患者，看看是否有好处， 特别是有氧健身的增加， 是可以维持的。该提案将建立一个受控的随机 一年居家有氧运动（踏楼梯）之研究 在家里进行上半身举重运动（这是不太可能的， 增加有氧健身）。 研究设计 结合了最先进的行为医学技术和强大的 以金钱为基础的奖励制度，以确保病人继续参与。 这样的计划对有氧健身的影响（以峰值氧气测量 消耗），运动耐量，肺功能，上身力量， 生活质量也将被衡量。 这种干预有可能 提高CF患者的体能、肺功能、生活质量， 甚至长寿

Cystic fibrosis (CF) is the most common inherited life-shortening disease among white populations, and is characterized by progressive loss of pulmonary function, exercise tolerance, and quality of life. Previous short-term studies have shown that patients with CF may benefit from aerobic exercise, with improved cardiopulmonary fitness, exercise tolerance, and perhaps either improvement or delay in the expected deterioration in lung function. Recent observations have confirmed a strong correlation between aerobic fitness and survival in patients with CF There have been no published studies that used behavioral medicine techniques to secure compliance with a long-term aerobic exercise program for patients with CF, aged 8 - 18 years, to see if the benefits, particularly the increase in aerobic fitness, seen with short programs could be sustained. This proposal would institute a controlled randomized study of one year of at-home aerobic exercise (stair-stepping) compared with at-home upper body weight-lifting exercise (that is unlikely to increase aerobic fitness) for patients with CF. The study design incorporates state-of-the-art behavioral medicine techniques and a strong money-based incentive system to secure patients' continued participation. The effects of such a program on aerobic fitness (measured as peak oxygen consumption), exercise tolerance, pulmonary function, upper body strength, and quality of life will be measured. This intervention has the potential to increase CF patients' fitness, pulmonary function, life-quality, and even longevity.