REPRODUCTIVE EXPERIENCE, DOPAMINE, AND MATERNAL BEHAVIOR

漏斗状多巴胺是催乳素的主要抑制物 在脑下垂体前叶内分泌哺乳细胞。生殖 体验可降低血液中催乳素和多巴胺水平 拮抗剂可刺激催乳素的释放。催乳素的这种抑制作用 出生和哺乳后的分泌物可能是长期的结果 漏斗结节多巴胺系统或多巴胺的变化 乳酸菌细胞表面的受体。世界银行的目标是 建议的研究是为了检查生育经验的影响。 正中隆起的多巴胺释放及其对神经功能的影响 突触后多巴胺受体。此外，我还将检查其效果。 关于催产素的生殖经验，催产素是另一种中枢抑制物 催乳素释放，两者都与催产素能调节 多巴胺释放和催产素降低的能力 催乳素释放。最后，我将研究生殖的影响 体验多巴胺介导的运动和母性行为。同舟共济 这些研究应该阐明观察到的长期变化 催乳素分泌的减少是由于漏斗结节的改变 DA系统，以及这种变化是否受中枢催产素的影响。 此外，这些研究将探讨优先平等的可能性。 影响对多巴胺能药物的行为反应。

Tuberoinfundibular dopamine is the predominant inhibitor of prolactin secreting lactotrophs within the anterior pituitary. Reproductive experience decreases both circulating prolactin levels and dopamine antagonist stimulated prolactin release. This dampening of prolactin secretion following birth and lactation may be the result of long-term changes in the tuberoinfundibular dopamine system or in the dopamine receptors on the cell surface of the lactotrophs. The goals of the proposed studies are to examine the effect of reproductive experience on dopamine release within the median eminance as well as the effect on postsynaptic dopamine receptors. In addition, I will examine the effect of reproductive experience on oxytocin, another central inhibitor of prolactin release, both with regard to oxytocinergic mediation of dopamine release as well as the ability of oxytocin to decrease prolactin release. Finally, I will examine the effect of reproductive experience of dopamine-mediated motoric and maternal behavior. Together these studies should elucidate whether the observed long-term changes in prolactin secretion are due to alterations in the tuberoinfundibular DA system and whether such changes are influenced by central oxytocin. Furthermore, these studies will address the possibility of prior parity influencing behavioral responses to dopaminergic drugs.