VERSATILE SYNTHESIS OF ANNONACEOUS ACETOGENINS

番荔枝内酯是一类增长迅速的天然产物 具有广泛的生物活性，包括抗肿瘤和 农药承诺该提案描述了一种通用的合成策略 使用催化闭环复分解（RCM）来获得几种 含有番荔枝内酯的相邻双-THF。RCM的使用是 扩展到合成四氢呋喃链段以及 许多乙酸配基共有的丁烯二酰末端以及 其他自然和非自然的目标。概述的提案 提出了替代协议，处理对称双-THF 核心结构以及那些缺乏完全对称性的结构。一个完整 提出了一种模型目标阿西米星的合成方法。

Annonaceous acetogenins are a rapidly growing class of natural products with a vast array of biological activities including anti-tumor and pesticidal promise. This proposal describes a versatile synthetic strategy using catalytic ring closing metathesis (RCM) for accessing several adjacent bis-THF containing Annonaceous acetogenins. The use of RCM is extended to the synthesis of both the tetrahydrofuran segment as well as the butenolide terminus common to many of the acetogenins as well as a host of other natural and unnatural targets. The outlined proposal presents alternative protocols that deal with both symmetrical bis-THF core structures as well as those lacking complete symmetry. A complete proposed synthesis of a model target asimicin is presented.