SUPERCOMPUTER SIMULATION OF THE MAMMALIAN KIDNEY

描述(改编自申请者的摘要)：总体目标 是在膜和分子水平上综合实验数据 转化为肾脏的预测数学模型，对 了解其正常和病变的功能。这位将军 拟议研究的目的是首次开发一种 数学和计算机模型，包括逼真的建筑， 水和溶质的细胞和细胞旁的运输和交换 血浆和红细胞之间的溶质和水。这个 开发建立在更简单的模型上，但需要并行 超级计算机的处理能力。

DESCRIPTION (Adapted from the applicant's abstract): The overall goal is to synthesize experimental data at the membrane and molecular level into predictive mathematical models of the kidney that are useful in understanding both its normal and diseased function. The general purpose of the proposed research is to develop for the first time a mathematical and computer model that includes a realistic architecture, cellular and paracellular transport of water and solutes, and exchange of solutes and water between plasma and red blood cells. The development builds on simpler models, but requires the parallel processing capabilities of supercomputers.