CORE--NEUROPSYCHOLOGY

神经心理学核心将促进计划项目的目标 并通过提供 量化所有人的认知和行为特征的资源 帕金森病（PD）患者和所有其他年轻人和老年人 受试者通过标准化神经心理测试。 一旦受试者 已被选定为可能的研究，在个别项目的人类 受试者/数据分析核心，神经心理学核心将筛选这些 受试者使用一套简短的神经心理学程序已经在 使用MADRC。 除了这个简短的评估，所有科目 接受项目l的低技术评估（因此那些正在接受 低技术任务的高技术分析）将额外管理一组 神经心理学的测量，包括特定的行为领域， 认为与拟议的生物力学研究相关（例如， 智力/精神状态、认知、运动能力、情感， 应对/适应。 认知领域包括以下具体措施： 注意力、问题解决能力、空间能力和心理表现。 该评估将提供更全面的描述， 病人的能力，扩大了普遍性， 调查结果，并允许更好地分析这些方面， 可能与运动控制有关的神经心理学表现。 内 总体目标是确定什么是关键的神经心理学 可能导致老年人行动障碍的因素， 神经心理学核心将是假设驱动的。 例如，我们期望 来证明这些认知之间越来越强的联系， 和行为/情感成分，并成功完成移动 任务的难度和复杂性的要求，在低技术 任务增加。 基本的简单运动和行为/情感成分 被期望对低难度低技术任务施加影响，而 认知的显著影响预计将在 高难度低科技任务 我们希望用我们的客观措施 心理能力与超额定仪器的结合 通过MADRC标准化使用的运动功能 为了进一步表征PD患者在这方面的功能， 计划，并通过对比这些措施， 他们与低技术和高技术流动性评估的结果。 那些 受试者不在项目1中，但正在接受其他高科技 任务将被赋予基本的MADRC筛选电池，以及一组 影响和应对/适应的措施。 此外，由于此前 我们项目的研究表明， 步态研究，如涉及跨越障碍物的研究， 受患者一般注意力的显著影响， 将采取集中注意力措施， 项目2中其他高科技任务测试中的患者。最后 神经心理学核心将协助提供更一般的验证， 通过一项评估，将个别项目的调查结果纳入总体提案， 评估所有受试者的一般功能状态。

The Neuropsychology Core will promote the goals of the Program Project and contribute directly to the individual projects by providing the resources for quantifying cognitive and behavioral characteristics of all Parkinson's disease (PD) patients and all other young and elderly subjects by standardized neuropsychological testing. Once subjects have been selected for possible study in the individual projects by the Human Subjects/Data Analysis Core, the Neuropsychology Core will screen these subjects using a brief set of neuropsychological procedures already in use by the MADRC. In addition to this brief assessment, all subjects receiving Project l's Lo-tech evaluations (and therefore those undergoing Hi-tech analyses of Lo-tech tasks) will be administered an additional set of neuropsychological measures including specific domains of behavior felt to be relevant to the proposed biomechanical studies (e.g., Intellect/Mental Status, Cognition, Motor Ability, Affect, Coping/Adaptation. The Cognitive domain includes specific measures of attention, problem solving, spatial ability, and psychomotor performance. This assessment will provide a more comprehensive description of patients' abilities in the Program, broadening the generalizability of the findings, and allow a finer analysis of those aspects of neuropsychological performance that may be tied to motor control. Within the overall goal of determining what are the critical neuropsychological factors that may underlie mobility impairments in the elderly, the Neuropsychology Core will be hypothesis driven. For example, we expect to demonstrate increasingly stronger associations between these cognitive and behavioral/affectual components and successful completion of mobility tasks as the difficulty and complexity of the demands in the Lo-tech tasks increase. Basic simple motor and behavioral/affectual components are expected to exert influence on low-difficulty Lo-tech tasks, whereas significant effects of cognition are expected to be evident on high-difficulty Lo-tech tasks. We expect to use our objective measures of psychomotor ability in conjunction with observer-rated instruments of motor functioning that have been standardized for use through the MADRC to further characterize the functioning of the PD patients in this program and to further our understanding of these measures by contrasting them with the results of the Lo- and Hi-tech mobility assessments. Those subject who are not in Project 1, but who are receiving the Other Hi-tech Tasks will be given the basic MADRC screening battery, as well as a group of measures of affect and coping/adaptation. Also, because previous research in our program has suggested that more complex and demanding gait studies, such as those involving stepping over barriers, may be significantly influenced by a patient's general attention and concentration specific attention measures will be administered to patients in the Other Hi-Tech Tasks testing in Project 2. Finally, the Neuropsychology Core will assist in providing more general validation for findings in individual projects in the overall proposal through an assessment of the general functional status of all subjects.