NEW JERSEY CFS CRC

作为对RFA AI-94-20的回应，Natelson博士及其同事建议： 继续开展粮安委合作研究中心的研究。 的 中心的中心主题和目标是使用CFS患者亚组 按生物学和神经/精神异常分层，以获得 深入了解病因和治疗。 该中心的目的将是继续整合诊断 最先进的病毒学和免疫学研究人员的能力， 一群擅长生理评估的医生和科学家 和心理学专家在精神和认知评估。 的 研究方法从病毒的遗传和细胞水平 再激活和细胞因子的产生，以器官水平的生理 功能，并到系统水平，以评估神经/心理 疾病模式和患者的健康状况。 在支持的前3年，疾病中心的修改 控制和预防（CDC）标准用于确定一组 突发性重症CFS患者，无精神病发病 他们表现出更多的认知障碍和更多的异常病毒或 慢性疲劳综合征（CFS）患者的免疫学参数比逐渐发作或目前 精神病诊断 这一富有成效的战略将扩大到包括 一组病情较轻的CFS患者，以比较 轻度和重度CFS。 为今后五年提出了一项三管齐下的战略， 中心的活动。 首先，从迄今为止获得的数据中综合出的想法 将推动旨在了解异常或原因的新研究 在CFS。 第二层规定每两年进行一次纵向测试， 确定CFS恢复的预测因素。 第三层是干预 一项体能训练的试验，以确定打破不活动的循环是否 可以使生理、认知、病毒/免疫损伤正常化， 增进健康。 这些高度合作的研究代表了整合 医学，心理学和生理学的结合 一个核心单位将提供 为所有研究项目提供行政和数据分析服务。

In response to RFA AI-94-20, Dr. Natelson and colleagues propose to continue the study of the CFS Cooperative Research Center (CRC). The central theme and goal of the Center is to use subgroups of CFS patients stratified by biological and neuro/psychiatric abnormalities to gain insight into etiology and treatment. The purpose of the Center will be to continue integrating the diagnostic capabilities of state-of-the-art virology and immunology researchers with a group of physicians and scientists expert at physiological evaluation and psychologists expert at psychiatric and cognitive assessment. The study approach moves from the genetic and cellular level of viral reactivation and cytokine production, to the organ level of physiological function, and to the system level to evaluate the neuro/psychological illness pattern, and fitness status of the patient. In the first 3 years of support, modifications of the Center for Diseases Control and Prevention (CDC) criteria were used to identify a group of severely ill CFS patients with sudden onset and no psychiatric morbidity who showed more cognitive impairment and more abnormal viral or immunologic parameters than CFS patients with gradual onset or current psychiatric diagnosis. This fruitful strategy will be extended to include a group of less severely ill CFS patients to allow comparisons between mild and severe CFS. A three-pronged strategy has been proposed for the next 5 years of the Center's activities. First, ideas synthesized from data obtained to date will fuel new studies aimed at understanding the abnormalities or causes of CFS. The second tier provides for biannual longitudinal testing to identify predictors of recovery in CFS. The third tier is an intervention trial of fitness training to determine if breaking the cycle of inactivity can normalize physiologic, cognitive, viral/immunologic impairments and improve health. These highly collaborative studies represent integration of medicine, psychology and physiology. One Core Unit will provide administrative and data analytic services to all research projects.