RENAL ISCHEMIA, DENDRITIC CELLS AND REJECTION

所有移植的肾脏在移植过程中都受到一定的缺血性损伤。 移植手术最近的数据表明，这种缺血可能 通过募集树突状细胞进入 肾脏树突状细胞对于启动免疫反应非常重要。 应答我们的具体目标是：1）了解 缺血对分子表达的影响（细胞分裂素/化学分裂素） 调节树突状细胞，2）研究ICAM-1和 E-选择素是树突状细胞外渗所必需的。 探讨这些问题将有助于更好地预防和 排斥的治疗。

All transplanted kidneys suffer some ischemic injury during the transplant procedure. Recent data indicate that this ischemia may initiate/exacerbate rejection by recruiting dendritic cells into the kidney. Dendritic cells are important for initiating immune responses. Our specific aims are: 1) to understand the effects of ischemia on the expression of molecules (cytokinines/chemokinines) which regulate dendritic cells, and 2) to investigate if ICAM-1 and E-selectin are necessary for dendritic cell extravasation. Answering those questions will allow for better prevention and treatment of rejection.