REGULATION OF ARTERIAL BAROREFLEX DURING DEVELOPMENT

本提案的总体目标是确定发展 胎儿和出生后动脉压力感受性反射的变化 并研究控制这些变化的机制。 的 第一个目标将是测试假设，增加 胎儿和新生儿生命期间的肾素-血管紧张素系统活性 有助于压力反射控制的发育变化， 心率和传出交感神经活动。 第二个目标 将是测试内源性的拟南芥素有助于 肾脏压力反射控制的敏感性增加 交感神经活动在发育早期。 第三个目标 这项申请的目的是检验一个假设， 加压素促进压力感受性反射介导的外周血中 胎儿和新生动物的交感神经活动。 这些研究 应该提供关于功能发展的新的重要信息， 动脉压力感受器反射和控制这些反射的机制 变化 对这些现象的充分理解尤其重要。 在胎儿和新生儿生命期间的意义，因为任何成熟 自主神经系统的改变可能会严重影响器官 流动，影响胎儿和出生后器官的生长和发育，导致 在以后的生活中发展高血压的倾向，并已 被认为是婴儿猝死综合症的潜在原因。

The overall objective of this proposal is to determine the developmental changes in the arterial baroreflex during fetal and postnatal life in sheep and to investigate the mechanisms controlling these changes. The first objective will be to test the hypothesis that the increased activity of the renin-angiotensin system during fetal and neonatal life contributes to the developmental changes in the baroreflex control of heart rate and efferent sympathetic nerve activity. The second objective will be to test the hypothesis that endogenous prostaglandins contribute to the increased sensitivity of the baroreflex control of renal sympathetic nerve activity early during development. The third objective of this application will be to test the hypothesis that circulating vasopressin facilitates the baroreflex-mediated reduction in peripheral sympathetic nerve activity in fetal and newborn animals. These studies should give new and important information on the functional development of the arterial baroreflex and of the mechanisms controlling these changes. Adequate understanding of these phenomena is of particular significance during fetal and neonatal life since any maturational alterations in the autonomic nervous system may acutely influence organ flow, affect fetal and postnatal organ growth and development, lead to predisposition of developing hypertension later in life, and have been suggested as a potential cause of the sudden infant death syndrome.