CODING OF BEHAVIORAL SEQUENCES IN THE BASAL GANGLIA

描述（改编自申请人的摘要）：本研究的目标 项目是了解基底神经节的神经机制， 介导行为序列。 基底神经节运动障碍， 如帕金森氏症和亨廷顿氏症， 严重丧失组织和执行序列的能力 运动 此外，基底神经节的认知障碍， 如图雷特综合症和强迫症所示， 顺序控制机制可能是基础药物的基本性质 神经节 在这个项目中，基底神经节中的单个神经元活动将被 与本能和习得的行为序列相关， 基底神经节协调序列，并确定基本 顺序组织的原则。 其他目标是 确定是否有不同的神经基板学习 和本能序列，并确定计算属性 序列相关的神经元组装在基底神经节。 有待检验的一个关键假设是基底节神经元活动 神经节将与梳理环境中的运动相关 序列，并不涉及这些运动时，他们发生在外面 这些序列。 将在大鼠中记录单个神经元， 刻板的顺序梳理，当动作的组成部分是 单独或以其他顺序模式制成。 最后，实验 将测试新纹状体神经元介导序列的假设， 调节感觉运动反应。 在这些实验中，神经元 黑质损伤后将记录活性， 破坏顺序梳理，或通过呈现皮肤和味觉刺激 在序列执行期间。

DESCRIPTION (Adapted from applicant's abstract): The goal of this project is to understand the neural mechanisms of the basal ganglia that mediate sequences of behavior. Motor disorders of the basal ganglia, such as Parkinson's and Huntington's disease, are associated with a profound loss of the ability to organize and execute sequences of movement. Furthermore, cognitive disorders of the basal ganglia such as Tourette's syndrome and obesessive compulsive disorder suggest that sequential control mechanisms may be a fundamental property of the basal ganglia. In this project, single neuron activity in the basal ganglia will be related to instinctive and learned behavior sequences to understand basal ganglia coordination of sequences, and to identify basic principles for sequential organization. Additional goals are to determine whether there are different neuronal substrates for learned and instinctive sequences and to determine the computational properties of sequence-related neuronal assemblies in the basal ganglia. A key hypothesis to be tested is that neuronal activity in the basal ganglia will be related to movements within the context of grooming sequences, and not related to these movements when they occur outside of these sequences. Single neurons will be recorded in rats during stereotyped sequential grooming and when components of movements are made in isolation or in other sequential patterns. Lastly, experiments will test the hypothesis that neostriatal neurons mediate sequences by modulating sensorimotor responsiveness. For those experiments, neuronal activity will be recorded after lesions of the substantia nigra, which disrupt sequential grooming, or by presenting cutaneous and taste stimuli during sequence execution.