CYTOCHROME P4501A1

大多数药物和其他外源性物质在注射前被广泛代谢。 淘汰 尽管这可以是有益的过程，例如， 作为其代谢活性衍生物的前药，代谢也可以 导致病理效应。 尽管已知几种酶系统 参与这一活动，细胞色素P450和含黄素 单加氧酶（FMO）被广泛认为是至少在 这一过程的初始步骤。 人工智能已经建立了一个活跃的 研究计划，以阐明控制表达的因素， 人CYP1A1基因和主要FMO。 目前的工作重点是 阻遏物与CYP1A1基因的相互作用， 其感应。 正在探索组织特异性控制机制 FMO1和2在兔子和BMO3在人类。 可能的多态性 在人类FMO3基因中的作用也在探索中。 AI目前有5个 全职博士和一名轮值博士 实验室里的学生。 学生 从药理学和癌症生物学研究生课程中招募。 在一个实验室或另一个工作的决定主要是基于 轮换经验。 很多时候，学生的论文项目是一个 在轮换期间延长工作。 学生有充足的 有机会参加部门研讨会和参加 日记俱乐部 在后者中，重点放在一个关键的 评价最近感兴趣的出版物。 实验室拥有 定期会议，鼓励实验室人员讨论 目前的结果和问题，他们可能会遇到的具体 实验方法。 学生们有机会帮助 审查认可机构收到的文件，以评估其在各种 编辑委员会。 还鼓励学生将他们的工作分单元， 国家会议，如果被接受，则为他们出席会议提供资金。 最后，人工智能已经建立了一个程序，以帮助学生留在 专注于他们的具体项目，这通常会导致一个良好的 出版记录和及时完成他们的研究生培训。

Most drugs and other xenobiotics are extensively metabolized prior to elimination. Although this can be a beneficial process, e.g. activation of a pro-drug to its pharmacologically active derivative, metabolism can also lead to pathological effects. Although several enzyme systems are known to participate in this activity, the cytochromes P450 and flavin-containing monooxygenases (FMO) are widely recognized as the major players in at least the initial steps of this process. The AI has established an active research program to elucidate factors controlling the expression of the human CYP1A1 gene and the predominant FMO. Current work is focused on the interaction of a repressor with the CYP1A1 gene which appears to modulate its inducibility. Tissue-specific control mechanisms are being explored for FMO1 and 2 in the rabbit and BMO3 in the human. Possible polymorphisms in the human FMO3 gene are also being explored. The AI currently has five full-time and one rotating Ph.D. students in his laboratory. Students are recruited both from the Pharmacology and Cancer Biology graduate programs. The decision to work in one laboratory or another are largely based on the rotation experience. Quite often, the students dissertation project is an extension of work performed during the rotation. Students have ample opportunities to attend departmental seminars and to participate in a journal Club. In the latter, an emphasis is placed on a critical evaluation of recent publications of interest. The laboratory holds regular meting wherein laboratory personnel are encouraged to discuss current results and problems they might be encountering in specific experimental approaches. Students are given the opportunity to help in the review of papers the AI receives for evaluation in his role on various editorial boards. Students are also encouraged to subunit their work to national meetings and if accepted, funds are provided for them to attend. Finally, the AI has established a process to aid the students in remaining focused on their specific projects which usually results in a good publication record and a timely finish to their graduate training.