RESEARCH AND TRAINING FOR BIOMEDICAL CAREER DEVELOPMENT

在约克学院MBRS计划的目标-“研究和培训 生物医学职业发展”-是为了改善和加强 研究环境，并扩大生物医学研究的范围， 大学的两个目的：（1）提高研究技能，增加 教师的学术生产力，（2）为少数人提供 学生有更多的机会获得知识，专业知识 和动机，将（1）引导他们走向生物医学职业生涯 研究和（B）使他们能够成功地竞争职位， 研究生院和专业学校。 为此目的，要求在以下方面提供支助： 7个项目涉及细胞生物学、物理化学、分子生物学 生物学，微生物和分子遗传学，有机化学， 社会学 还要求为14名将参加的学生提供支助 在规划和实施研究的所有阶段，以及 如报告和公布结果。 在项目#1中， “简单卟啉的电子光谱”，激发电子态 将研究模型生物发色团。 在项目#2“序列 和果蝇5SRNA加工的结构信号”， 将产生和分析突变RNA。 项目#3“研究 IS 2转座的机制”将开发一种体内转座 分子间和分子内转座事件可通过其 研究了 在项目#4中，“暴露于慢性社区暴力及其 后果”的心理和身体疾病的影响，这一点 将研究环境压力。 项目#5，“环扩张1，3 二杂核苷”，将调查立体化学的要求， 通过控制合成1，3-二杂核苷的抗病毒活性 以及在项目#6，“用于蛋白质NMR的独特标记的氨基酸”，2 H， 13 C和15 N标记的氨基酸将被合成并掺入到 通过溶液和固态NMR进一步研究蛋白质。 次级项目4 是mBRS提案的新内容。 所有其他子项目都是 MBRS补助金目前由约克学院持有。

The objectives of the MBRS program at York College - "Research and Training for Biomedical Career Development" - are to improve and strengthen the research environment and to broaden the scope of biomedical research in the college for two purposes: (1) to improve the research skills and increase the scholarly productivity of the faculty, and (2) to provide the minority students with increased opportunities to acquire the knowledge, expertise and motivation that will (1) direct them towards careers in biomedical research and (b) enable them to successfully compete for positions in graduate and professional schools. To these ends support is requested for 7 projects ina the areas of cell biology, physical chemistry, molecular biology, microbial and molecular genetics, organic chemistry, and sociology. Support is also requested for 14 students who will participate in all phases of the planning and implementation of the research, as well as in the reporting and publication of the results. In project #1, "Electronic Spectroscopy of Simple Porphyrins", excited electronic states of model biological chromophores will be studied. In project #2 "Sequence and Structure Signals for 5SRNA processing in Drosophila melanogaster", mutant RNAs will be produced and analyzed. Project #3 "Studies on the Mechanism of IS2 Transposition" will develop an in vivo transpositional assay by which inter and intramolecular transposition events can be studied. In Project #4, "Exposure to Chronic Community Violence and Its Consequences" the psychological an physical illness effects of this environmental stress will be studied. Project #5, "Ring Expanded 1,3 Dihetero Nucleosides", will investigate stereochemical requirements for antiviral activity by the controlled synthesis of 1,3 dihetero nucleosides and in project #6, "Uniquely Labelled Amino Acids for Protein NMR", 2H, 13C, and 15N labelled amino acids will be synthesized and incorporated into proteins for further study by solution and solid state NMR. Subproject #4 is new to this mBRS proposal. All other subprojects are components of the MBRS grant currently held by York College.