SMOKELESS TOBACCO--NICOTINE PATCH & SELF HELP TREATMENT

无烟烟草的使用是一个严重的健康威胁，约6 100万经常使用这种药物的人导致各种癌症和其他疾病， 健康问题1990 - 1991年加州基线吸烟调查发现， 北方加州的一个无烟烟草使用率高的地区 成年男性的比例为10.4%，而整个 全国6%，全国6%。目前我们所知甚少 戒烟的有效方法无烟烟草。迄今为止， 只有三项已发表的成人无烟戒烟研究 干预措施。这些已发表的研究都没有审查使用 尼古丁替代疗法 在这项研究中，我们建议进行一项随机实验， 自助材料加尼古丁贴片和自助的效果 材料加安慰剂贴剂与400名无烟烟草使用者。在这 双盲研究，受试者将通过电话进行筛选和访谈 并从接受过研究培训的药剂师那里获得材料和贴片 议定书所有受试者将在接受 干预，并将提供电话支持/咨询 大约在他们设定的戒烟日期后一周。所有400无烟 烟草使用者将在基线、3个月、6个月和12个月进行评估， 在6个月时进行烟草使用状态的可替宁验证。 除了随机试验外，我们还建议研究一种通用的 通过以下方式选择无烟烟草使用者的人群样本（N = 150）： 随机数字拨号电话采访，以探索 一般无烟烟草使用者和参与- 停止干预。将在基线和 3、6和12个月间隔。

Smokeless tobacco use is a serious health threat to the approximately 6 million regular users of the drug causing various cancers and other health problems. The California Baseline Smoking Survey 199O-1991 found a region in northern California which had a smokeless tobacco use rate of 10.4% among their adult males as compared to a 3.5% rate across the whole state and 6% nationally. Very little is currently known about effective methods of cessation for smokeless tobacco. To date there have been only three published studies of adult smokeless tobacco cessation interventions. None of these published studies has examined the use of nicotine replacement therapy. In this study we propose to conduct a randomized experiment comparing the effectiveness of self-help materials plus nicotine patch and self-help materials plus placebo patch with 400 smokeless tobacco users. In this double blind study, subjects will be screened and interviewed by phone and receive materials and patches from pharmacists trained in the study protocol. All subjects will set a quit date prior to receiving the intervention and will be provided with phone support/counseling approximately one week after their set quit date. All 400 smokeless tobacco users will be assessed at baseline,3, 6, and 12 months and saliva cotinine verification of tobacco use status will be done at 6 months. In addition to the randomized trial, we propose to study a general population sample (N=150) of smokeless tobacco users selected through random-digit dial telephone interviewing to explore differences between smokeless tobacco users in general and users who participate in the- cessation interventions. The sample will be measured at baseline and at 3, 6, and 12 month intervals.