SIGNAL ACQUISITION AND ANALYSIS IN CARDIAC MAPPING

描述（改编自申请人的摘要）： 一项拟议的研究是绘制一个人的室颤发作， 清醒的动物模型，包括陈旧性梗死加急性缺血。 纤颤期间的激活波前将通过记录 来自126个长期植入的壁内电极。3D解剖学 陈旧性梗死的发生率、缺血的程度和 将确定纤维性颤动时的自主神经系统。 调查人员将确定预先存在的 梗塞增加了由急性缺血引起的纤维性颤动的发生率。 他们将确定（1）起始搏动的起源部位， 纤维性颤动，例如，内侧缘、侧缘或中央缘 部分缺血床，（2）的机制，这第一次跳动 发生，例如，（3）旧的机制， 梗塞使纤维性颤动更可能，例如，直接地，通过形成 二次折返回路在梗死区，或间接通过 改变自主神经张力，使二次折返更容易发生 到梗死区以外。初步研究将在 心律失常的时间可以预测到一个 因此，可以使用当前可用映射来执行 仪器仪表为了研究更真实的猝死， 研究人员建议开发遥测方法来记录和分析 数据来自长达数月的长期植入电极。 他们将使用这种技术从仪器中记录长期的 不受束缚的动物这将允许对动物的监测 其中纤维性颤动的时间不能被预期，例如突然的 有陈旧性梗死或慢性心力衰竭但没有 急性缺血

DESCRIPTION (adapted from the applicant's abstract): The goal of the proposed research is to map the onset of ventricular fibrillation in a conscious animal model consisting of an old infarct plus acute ischemia. Activation wavefronts during fibrillation will be determined by recording from 126 chronically implanted intramural electrodes. The 3D anatomy of the old infarct, the degree of ischemia, and the status of the autonomic nervous system at the time of fibrillation will be determined. The investigators will determine the mechanism by which a pre-existing infarct increases the incidence of fibrillation caused by acute ischemia. They will determine (1) the site of origin of the initiating beat of fibrillation, e.g., the endocardial border, lateral border or central portion of the ischemic bed, (2) the mechanism by which this first beat occurs, e.g., reentry or focal, (3) the mechanism by which the old infarct makes fibrillation more likely, e.g., directly, by forming secondary reentrant circuits in the infarcted region, or indirectly by changing autonomic tone so that secondary reentry occurs more readily outside to infarcted region. Initial studies will be carried out in models in which time of the arrhythmias can be predicted to within one hour and, hence, can be performed using currently available mapping instrumentation. In order to study more realistic sudden death, the investigators proposes to develop telemetry methods to record and analyze data from chronically implanted electrodes for up to several months. They will use this technology to record long-term from instrumented animals that are untethered. This will allow the monitoring of animals in which the time of fibrillation cannot be anticipated, such as sudden death in which there is an old infarct or chronic heart failure but no acute ischemia.