CALCIUM/CALMODULIN SIGNALS & ACTIVATION OF CAM KINASEII

钙调蛋白被认为是信号中最重要的钙感受器 转导。当钙调素上的四个钙结合部位是 占据，钙调蛋白成为多功能激活剂，调节 大量的关键细胞功能，特别是在 中枢神经系统。然而，人们对这一巨大的 钙调素依赖的细胞功能的数量可以选择性地 控制住了。在提议的实验中，我将定义基本的 钙调素可用性在太空和太空中的调节机制 时间和研究这种局部钙调蛋白调节的重要性 用于Cam KinaseII功能。这些研究将在生活中进行 培养的海马神经元。

Calmodulin is thought to be the most important calcium sensor in signal transduction. When the four calcium binding sites on calmodulin are occupies, calmodulin becomes a multifunctional activator that regulates a large number of critical cell functions, particularly in neurons of the central nervous system. However, little is known about how the large number of calmodulin-dependent cell functions can be selectively controlled. In the proposed experiments, I will define the fundamental mechanisms by which calmodulin availability is regulated in space and time and investigate the importance of this local calmodulin regulation for CaM kinaseII function. These studies will be carried out in living cultured hippocampal neurons.