BRAIN ERPS AND COGNITIVE DEMAND IN SCHIZOPHRENIA

描述(摘自申请者摘要)：精神分裂症患者 已经显示P3脑事件相关电位的幅度降低到音调，这是 最大超过左侧颞叶部位。在最初的项目期间， 研究人员在一项二分复音任务中重复了这一发现，并 发现精神分裂症患者的氮气波幅降低和不对称性 双音节任务。这表明左脑功能障碍 言语加工精神分裂症早在刺激后200毫秒就会出现 开始了。精神分裂症患者中的N2异常在两种情况下都存在 听觉和视觉任务，而P3异常似乎是通道 具体的。调查人员提议进行四项研究，以确定 产生这些ERP所需的任务和患者特征 并进一步解决其神经生理机制。 研究1将记录大样本精神分裂症患者的事件相关电位(n=120) 和正常对照组(n=40)进行言语和非言语的双耳古怪任务， 并将评估响应模式(静默计数，右手)的影响 或左手)。这些大样本将使调查员能够检查 精神分裂症患者事件相关电位异常与症状特征的关系 抗精神病药物的治疗结果，精神分裂症的家族史， 和神经成像手段。研究2将开发和应用新的语言和 结合二分听力优势的非语言任务 程序，但使用了一个简单古怪的范例。研究3比较了以下几种情况的事件相关电位 精神分裂症患者和对照组的听、视连续词研究 识别任务，被认为是反映左内侧颞叶 功能。研究4继续研究人员对视觉空间的研究 在精神分裂症患者中使用一种旨在解开纠缠的修订范式 选择性注意和后来的认知加工的影响。病人 将在停药期间进行测试，并在治疗六周后再次进行测试 使用氟哌啶醇或非典型抗神经药(氯氮平或利培酮)。一个 更长远的临床目标是为发展 可预测常规或非典型治疗反应的测试 治疗精神分裂症的抗精神病药物。

DESCRIPTION (Adapted from applicant's abstract): Schizophrenic patients have shown a reduction in amplitude of the P3 brain ERP to tones, which was maximal over left temporal lobe sites. In the initial project period, the investigator replicated this finding in a dichotic complex tone task and found reduced N2 amplitude and asymmetry in schizophrenic patients in a dichotic syllable task. This suggests that left hemisphere dysfunction in schizophrenia for verbal processing occurs as early as 200 ms after stimulus onset. N2 abnormalities in schizophrenic patients were present in both auditory and visual tasks, whereas P3 abnormalities appear to be modality specific. The investigator proposes to conduct four studies to determine the task and patient characteristics necessary for producing these ERP abnormalities and to further resolve their neurophysiologic mechanisms. Study 1 will record ERPs in a large sample of schizophrenic patients (n=120) and normal controls (n=40) on verbal and nonverbal binaural oddball tasks, and will assess the influence of response mode (silent counting, right hand or left hand). These large samples will enable the investigator to examine the relation of ERP abnormalities in schizophrenia to symptom features, outcome of treatment with neuroleptics, familial history of schizophrenia, and neuroimaging measures. Study 2 will develop and apply new verbal and nonverbal tasks that incorporate advantages of dichotic listening procedures, but utilize a simple oddball paradigm. Study 3 compares ERPs of schizophrenic patients and controls in auditory and visual continuous word recognition tasks, which are thought to reflect left medial temporal lobe function. Study 4 continues the investigator's study of visuospatial processing in schizophrenia using a revised paradigm designed to disentangle effects of selective attention and later cognitive processing. Patients will be tested while off medication and again after six weeks of treatment with haloperidol or an atypical neuroleptic (clozapine or risperidone). A more long range clinical goal is to contribute toward the development of tests that could predict response to treatment with conventional or atypical neuroleptic medications for schizophrenia.