Subtypes of Schizophrenia: ERPs During Memory Processing

精神分裂症的亚型：记忆处理过程中的 ERP

• 批准号: 6722440
• 负责人: GERARD E BRUDER
• 金额: $ 35.96万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6722440
• 关键词: antipsychotic agents; attention; behavior test; behavioral /social science research tag; brain electrical activity; clinical research; evoked potentials; face; family genetics; human middle age (35-64); human subject; language; learning; memory; neural information processing; neurophysiology; neuropsychological tests; performance; problem solving; psychopharmacology; schizophrenia; short term memory; visual perception; young adult human (21-34)

DESCRIPTION (provided by applicant): Working memory and episodic memory impairments are present in patients with schizophrenia and their relatives, suggesting that it may represent a "cognitive phenotype" of schizophrenia. This project proposes to use brain event-related potentials (ERPs) and behavioral measures to study both working memory and recognition memory for words and faces in patients with schizophrenia. The fine temporal resolution of ERPs will aid in determining the specific stages of processing (encoding, storage and retrieval) associated with abnormalities on these memory tests. Preliminary ERP findings during a word serial position test suggest that a left-frontal slow wave associated with short-term storage of words is reduced in schizophrenia patients, and abnormalities during a word recognition memory test are evident as early as 100 to 200 milliseconds after stimulus onset. Recording ERPs to both words and faces will provide additional information concerning material-specificity of abnormalities of memory function and cerebral laterality in schizophrenia. ERPs of 60 unmedicated schizophrenic patients, 60 patients receiving an atypical antipsychotic, and 60 healthy controls will be recorded during serial position tests and recognition memory tests with word and face stimuli. Patients and controls will also be tested on standard neurocognitive tests of attention (CPT), learning and memory (WMS-R), and problem solving (WCST). Unmedicated patients, medicated patients and healthy controls will be compared to determine whether differences in their performance and brain ERPs on these tests are related to medication status. In addition, ERP and behavioral data for patient subgroups and controls will be compared so as to contribute toward the identification and validation of "cognitive subtypes" with more homogeneous clinical and biological characteristics. A series of studies has identified a subgroup of patients who perform as well as healthy adults on a screening test of attention and tonal perception, but who have a selective deficit in verbal memory (discriminators, Dsz), while a second subgroup of patients, who perform poorly on the screening test, show evidence of a generalized cognitive deficit (non-discriminators, NDsz). The project aims to further validate these subgroups by testing hypothesized differences in their material-specific memory function, ERP abnormalities during different phases of memory processing, deficits on standard neurocognitive tests, and symptom features.

描述（由申请人提供）：精神分裂症患者及其亲属存在工作记忆和情景记忆障碍，表明其可能代表精神分裂症的“认知表型”。本研究拟采用脑事件相关电位（ERP）和行为测量方法，研究精神分裂症患者对文字和面孔的工作记忆和再认记忆。ERP的精细时间分辨率将有助于确定与这些记忆测试异常相关的特定处理阶段（编码，存储和检索）。在一个单词序列位置测试的初步ERP结果表明，左额叶慢波与短期存储的话是减少精神分裂症患者，在一个单词识别记忆测试的异常是明显的，早在100至200毫秒刺激发作后。记录文字和面孔的ERPs将提供有关精神分裂症记忆功能异常和大脑偏侧化的材料特异性的额外信息。60例未用药的精神分裂症患者、60例接受非典型抗精神病药的患者和60例健康对照者的ERP将在连续位置测试和使用单词和面部刺激的识别记忆测试期间被记录。还将对患者和对照组进行注意力（CPT）、学习和记忆（WMS-R）以及问题解决（WCST）的标准神经认知测试。将比较未用药患者、用药患者和健康对照，以确定这些测试中的表现和脑ERP差异是否与用药状态相关。此外，将比较患者亚组和对照组的ERP和行为数据，以有助于识别和验证具有更同质的临床和生物学特征的“认知亚型”。一系列的研究已经确定了一个亚组的患者，他们在注意力和音调感知的筛查测试中表现得和健康成年人一样好，但是他们在言语记忆中有选择性缺陷（辨别器，Dsz），而第二个亚组的患者，他们在筛查测试中表现不佳，显示出广义认知缺陷的证据（非辨别器，NDsz）。该项目旨在进一步验证这些亚组，通过测试他们的特定材料的记忆功能，ERP异常在不同阶段的记忆处理，标准的神经认知测试和症状特征的赤字假设的差异。