Mechanisms of itch - from endosomal signalling to neural circuits

本项目旨在通过定义瘙痒特异性信号的激活和传播来研究脊髓中瘙痒传递的细胞和电路机制。该项目希望在神经元信号和电路领域产生新的知识，使用新的电生理学方法，针对和操纵特定的神经和细胞成分。该项目将描述特定脊髓亚回路中的信号传导，以了解受体激活和信号传导的机制，并研究回路活动是如何调节的。该项目有望促进对神经系统瘙痒信号的基本理解，并为未来的治疗提供途径。

This project aims to investigate the cellular and circuit mechanisms of itch transmission in the spinal cord by defining the activation and propagation of itch-specific signals. This project expects to generate new knowledge in the area of neuronal signalling and circuitry using novel electrophysiological approaches that target and manipulate specific nerves and cellular components. The project will characterise signalling within specific spinal subcircuits in order to understand the mechanisms of receptor activation and signalling, and investigate how circuit activity is regulated. This project expects to advance fundamental understanding of itch signalling in the nervous system and provide avenues for future therapeutics.