MICROBE PATHOGEN GENOME PROJECT--A ACTINOMYCETEMCOMITANS

描述（改编自研究者摘要）：在此 应用程序，研究人员建议确定核苷酸序列 放线共生放线杆菌（Actinobacillusactinomycetemcomitans，以下简称放线杆菌）的基因组 Aa出于明显的原因）。 AA是局限性青少年的病原体 牙周炎（LJP），困扰至少70，000名儿童和青少年 每年在美国。 LJP是牙龈的慢性炎症性疾病 （牙龈）和下面的骨组织，没有有效的预防。 最近 数据表明，Aa也参与了其他牙周疾病， 综合征，并导致危及生命的口外感染。 分类学 Aa与流感嗜血杆菌密切相关。 这是一个高度 Aa基因组测序计划的一个吸引人的特点。 从视点 微生物发病机理的学生，H。流感病毒基因组序列 有几个具体的问题，尽管它非常重要， 成就 这些研究将避免危害H。 流感病毒数据库。 事实上，Aa基因组序列可以增强 H.的效用。流感病毒序列，除了提供重要的 关于Aa的信息因此，研究人员提出了一个单一的具体目标， 本项目：测定和分析2.2Mb的核苷酸序列， Aa菌株CU1000的基因组。

DESCRIPTION (Adapted from the Investigator's Abstract): In this application, the investigators propose to determine the nucleotide sequence of the genome of Actinobacillus actinomycetemcomitans (hereafter abbreviate Aa for obvious reasons). Aa is the causative agent of localized juvenile periodontitis (LJP), afflicting at least 70,000 children and adolescents each year in the US. LJP is a chronic inflammatory disease of the gingiva (gums) and underlying bony tissues, with no effective prevention. Recent data suggests that Aa is also involved in other periodontal disease syndromes, and causes life-threatening extraoral infections. Taxonomically Aa is closely related to Haemophilus influenzae. This is a highly attractive feature of the Aa genome sequencing project. From the viewpoint of a student of microbial pathogenesis, the H. influenzae genome sequence has several specific problems, despite the singular importance of that achievement. The studies will avoid pitfalls that compromised the H. influenzae database. Indeed, the Aa genomic sequence may enhance the utility of the H. influenzae sequence, in addition to providing important information on Aa. Thus, the investigators propose a single specific aim for the project: to determine and analyze the nucleotide sequence of the 2.2 Mb genome of Aa strain CU1000.