Investigating a new way in which diet impacts animal biology

该项目旨在研究饮食改变动物生物学的新方法的重要性。高脂肪或高糖饮食增加了代谢产物与染色体的结合，这可以完全改变DNA的包装和阅读方式。该项目将使用细胞培养、啮齿动物和苍蝇模型来识别受新过程影响最大的基因组区域。该项目还将确定细胞是否受到伤害，或者实际上利用该过程来控制发育或代谢。这个项目对我们理解基因与环境相互作用的方式有影响，特别是在变化时期。

This project aims to investigate the importance of a new way in which diet can alter animal biology. High fat or high sugar diets increase the binding of products of metabolism to chromosomes, which can completely alter the way that DNA is packaged and read. This project will use cell culture, rodent and fly models to identify the regions of the genome that are most affected by the new process. The project will also determine whether the cell is harmed, or in fact harnesses the process to control development or metabolism. This project has implications for our understanding of the ways in which genes interact with the environment especially in times of change.