PROTEIN LOCALIZATION OF THE YEAST VACUOLE
PROTEIN LOCALIZATION OF THE YEAST VACUOLE
批准号:
2713766
负责人:
BRUCE F HORAZDOVSKY
金额:
$18.57万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-06-01 至 2002-05-31
中文摘要
描述:这项研究的长期目标是确定
溶酶体蛋白向细胞转运的分子事件
酵母溶酶体,相当于液泡。此应用程序侧重于
与RAS类似的GTP酶Vps21p和Sec1同源物Vps45p被证明是重要的
在空泡蛋白分选中。Horazdovsky博士将准确地定义这一步骤
在那里这些蛋白质起作用,并开始寻找相互作用的蛋白质和
它们对Vps21p的调制机制。其他目标包括分析
将携带高尔基体衍生蛋白的小泡运输到液泡,以及
蛋白酶A分选蛋白的特性研究。
英文摘要
DESCRIPTION: The long term goal of this research is to determine the
molecular events which underlie the transport of lysosomal proteins to the
yeast lysosome-equivalent, the vacuole. This application focuses on a
Ras-like GTPase, Vps21p, and a Sec1 homolog, Vps45p, shown to be important
in vacuolar protein sorting. Dr. Horazdovsky will define precisely the step
at which these proteins act, and begin to look for interacting proteins and
their mechanisms of modulation of Vps21p. Other aims include analysis of
transport vesicles carrying Golgi derived proteins to the vacuole, and
characterization of the proteinase A sorting proteins.
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会议论文
Institutional Short-Term Research Training for Students of Diversity
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批准号:7474418
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项目类别:
-
资助金额:$9.46万
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财政年份:2008
-
负责人:BRUCE F HORAZDOVSKY
-
依托单位:
Institutional Short-Term Research Training for Students of Diversity
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批准号:8237047
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项目类别:
-
资助金额:$14.95万
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财政年份:2008
-
负责人:BRUCE F HORAZDOVSKY
-
依托单位:
Institutional Short-Term Research Training for Students of Diversity
-
批准号:10410367
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项目类别:
-
资助金额:$16.09万
-
财政年份:2008
-
负责人:BRUCE F HORAZDOVSKY
-
依托单位:
Institutional Short-Term Research Training for Students of Diversity
-
批准号:8052833
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项目类别:
-
资助金额:$14.95万
-
财政年份:2008
-
负责人:BRUCE F HORAZDOVSKY
-
依托单位:
Institutional Short-Term Research Training for Students of Diversity
-
批准号:7612709
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项目类别:
-
资助金额:$10.66万
-
财政年份:2008
-
负责人:BRUCE F HORAZDOVSKY
-
依托单位:
Institutional Short-Term Research Training for Students of Diversity
-
批准号:10606565
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项目类别:
-
资助金额:$16.09万
-
财政年份:2008
-
负责人:BRUCE F HORAZDOVSKY
-
依托单位:
Institutional Short-Term Research Training for Students of Diversity
-
批准号:7860600
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项目类别:
-
资助金额:$12.55万
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财政年份:2008
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负责人:BRUCE F HORAZDOVSKY
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依托单位:
Cell Surface Receptor Trafficking
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批准号:6914426
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项目类别:
-
资助金额:$24.66万
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财政年份:2003
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负责人:BRUCE F HORAZDOVSKY
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依托单位:
Cell Surface Receptor Trafficking
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批准号:6563013
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项目类别:
-
资助金额:$26.77万
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财政年份:2003
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负责人:BRUCE F HORAZDOVSKY
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依托单位:
Cell Surface Receptor Trafficking
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批准号:7085471
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项目类别:
-
资助金额:$24.08万
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财政年份:2003
-
负责人:BRUCE F HORAZDOVSKY
-
依托单位:
Cell Surface Receptor Trafficking
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批准号:6766961
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项目类别:
-
资助金额:$24.66万
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财政年份:2003
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负责人:BRUCE F HORAZDOVSKY
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依托单位:
PROTEIN LOCALIZATION OF THE YEAST VACUOLE
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批准号:2023872
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项目类别:
-
资助金额:$19.09万
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财政年份:1997
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负责人:BRUCE F HORAZDOVSKY
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依托单位:
Regulation of intracellular protein traffic
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批准号:7058749
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项目类别:
-
资助金额:$25.98万
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财政年份:1997
-
负责人:BRUCE F HORAZDOVSKY
-
依托单位:
Regulation of intracellular protein traffic
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批准号:6891345
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项目类别:
-
资助金额:$26.6万
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财政年份:1997
-
负责人:BRUCE F HORAZDOVSKY
-
依托单位:
PROTEIN LOCALIZATION TO THE YEAST VACUOLE
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批准号:6180661
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项目类别:
-
资助金额:$19.67万
-
财政年份:1997
-
负责人:BRUCE F HORAZDOVSKY
-
依托单位:
Regulation of intracellular protein traffic
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批准号:6740193
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项目类别:
-
资助金额:$26.6万
-
财政年份:1997
-
负责人:BRUCE F HORAZDOVSKY
-
依托单位:
PROTEIN LOCALIZATION TO THE YEAST VACUOLE
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批准号:6017100
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项目类别:
-
资助金额:$19.11万
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财政年份:1997
-
负责人:BRUCE F HORAZDOVSKY
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依托单位:
Regulation of intracellular protein traffic
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批准号:6572790
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项目类别:
-
资助金额:$28.88万
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财政年份:1997
-
负责人:BRUCE F HORAZDOVSKY
-
依托单位:
PROTEIN LOCALIZATION TO THE YEAST VACUOLE
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批准号:6386658
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项目类别:
-
资助金额:$20.24万
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财政年份:1997
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负责人:BRUCE F HORAZDOVSKY
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依托单位:
Institutional Short-Term Research Training for Minority
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批准号:6899844
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项目类别:
-
资助金额:$0.0万
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财政年份:1992
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负责人:BRUCE F HORAZDOVSKY
-
依托单位: